Hydroquinone + Hydrocortisone + Tretinoin Pharmacology

Hydroquinone + Hydrocortisone + Tretinoin

About Hydroquinone + Hydrocortisone + Tretinoin

N/A

Mechanism of Action of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Pharmacokinets of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Onset of Action for Hydroquinone + Hydrocortisone + Tretinoin

N/A

Duration of Action for Hydroquinone + Hydrocortisone + Tretinoin

N/A

Half Life of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Side Effects of Hydroquinone + Hydrocortisone + Tretinoin

1.Dryness
2.Erythema
3.Stinging and occasional hypersensitivity of the bleached skin

Contra-indications of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Special Precautions while taking Hydroquinone + Hydrocortisone + Tretinoin

N/A

Pregnancy Related Information

Contraindicated

Old Age Related Information

N/A

Breast Feeding Related Information

Contraindicated

Children Related Information

N/A

Indications for Hydroquinone + Hydrocortisone + Tretinoin

1.Melasma
2.Freckles
3.Hyperpigmentation

Interactions for Hydroquinone + Hydrocortisone + Tretinoin

N/A

Typical Dosage for Hydroquinone + Hydrocortisone + Tretinoin

Once daily in the evening or exactly as directed by your doctor

Schedule of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Storage Requirements for Hydroquinone + Hydrocortisone + Tretinoin

Store in a well closed container. Keep out of the reach of children

Effects of Missed Dosage of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Effects of Overdose of Hydroquinone + Hydrocortisone + Tretinoin

N/A

Hydroquinone

About Hydroquinone

Benzenediol derivative, Depigmenting Agent.

Mechanism of Action of Hydroquinone

Hydroquinone decreases the formation of melanin in the skin. It inhibits tyrosinase and other melanin forming enzymes and thus decreases the formation and increases the degradation of melanosomes.

Pharmacokinets of Hydroquinone

Absorption: Administered topically.

Onset of Action for Hydroquinone

N/A

Duration of Action for Hydroquinone

N/A

Half Life of Hydroquinone

N/A

Side Effects of Hydroquinone

1. Skin irritation
2. Allergic reactions
3. Rashes
4. Burning
5. Stinging
6. Itching
7. Redness
8. Irritation

Contra-indications of Hydroquinone

1. Hypersensitivity to the drug

Special Precautions while taking Hydroquinone

1. Discontinue the drug if skin irritation occurs
2. Care should be taken to avoid it`s entry to eyes, nose, lips or mouth
3. Avoid exposure to sunlight
4. Use a sunscreen and wear protective clothing when exposure to the sun
5. Do not use hydroquinone topical on burned, dry, chapped, or irritated skin, or on an open wound. It could make these conditions worse
6. Hepatic impairment
7. Renal impairment
8. Along with other topical medication on the same area

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

Use with caution

Children Related Information

Contraindicated

Indications for Hydroquinone

1. Melasma
2. Freckles
3. Hyperpigmention
4. Lentigo

Interactions for Hydroquinone

N/A

Typical Dosage for Hydroquinone

2 to 6% cream or lotion for months as required. Apply evenly on the affected areas two times daily; in the morning and evening. Massage the cream on the skin.

Schedule of Hydroquinone

N/A

Storage Requirements for Hydroquinone

Store at room temperature at a range of 15 to 30 degree C. Protect from moisture and heat. Do not freeze and keep out of reach of children.

Effects of Missed Dosage of Hydroquinone

Use the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Hydroquinone

Rinse with water and Provide symptomatic treatment and supportive measures.

Hydrocortisone

About Hydrocortisone

Systemic synthetic glucocorticoid, anti-inflammatory

Mechanism of Action of Hydrocortisone

The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts both glucocorticoid and mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.

Pharmacokinets of Hydrocortisone

Absorption: Absorption ranges from 1% to 36% after topical application. Absorption after injection varies depending up on the site of injection and blood supply to particular area.
Distribution: After topical application distributed throughout the local skin layers. Any drug absorbed in to circulation is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine. Metabolism: Metabolized primarily in skin after topical application and a small amount absorbed in to circulation is metabolized in liver. Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.

Onset of Action for Hydrocortisone

N/A

Duration of Action for Hydrocortisone

N/A

Half Life of Hydrocortisone

N/A

Side Effects of Hydrocortisone

1. Burning
2. Irritation
3. Pruritus
4. Dryness
5. Erythema
6. Folliculitis
7. Hypertrichosis
8. Acneiform eruptions
9. Allergic contact dermatitis
10. Secondary infections
11. Atrophy
12. Striae
13. Suppression of adrenocorticotropic hormone
14. Cushing`s syndrome
15. Glucosuria
16. Hyperglycaemia
17. Fluid retention
18. Sodium retention
19. Hypokalaemia
20. Oedema
21. Weakness
22. Muscle wasting
23. Gastrointestinal discomfort
24. Peptic ulcer
25. Haemorrhage
26. Joint damage
27. Fibrosis
28. Headache
29. Convulsions
30. Vertigo
31. Increased intracranial pressure
32. Depression
33. Local hypopigmentation

Contra-indications of Hydrocortisone

1. Hypersensitivity to the drug
2. Not to be given I.V. or I.M.
3. Local or systemic infections
4. Fungal or herpetic keratitis
5. Cataract
6. Tubercular or syphilitic lesions.

Special Precautions while taking Hydrocortisone

1. Occlusive dressings (Topical preparation)
2. Use of potent preparations should be short term or intermittent
3. Milder drugs should be used in acute lesions and stronger ones are for chronic lesions
4. Avoid sudden discontinuation of the drug
5. Hypothyroidism
6. Cirrhosis
7. Stress
8. Sepsis
9. Ocular herpes simplex
10. Peptic ulcer
11. Hypertension
12. Osteoporosis
13. Myasthenia gravis
14. Renal impairment
15. Ulcerative colitis
16. Diverticulitis

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
NEONATES : Contraindicated

Indications for Hydrocortisone

Intra-articular injection :
1. Rheumatoid arthritis
2. Gouty arthritis
3. Osteoarthritis
4. Joint sequelae of fractures and dislocations
5. Other inflammatory conditions of joints.
Periarticular or soft tissue injections:
1. Bursitis
2. Synovitis
3. Tendinitis
4. Taenosinovitis
5. Cystic tumors of tendon or aponeurosis
6. Epicondylitis
7. Scapulo-humeral periarthritis
8. Periarthritis of hip
9. Tarsalgias
10. Meta-tarsalgias
11. Dupuytren`s contracture
12. Peyronie`s disease.

Intra-lesional injections:
1. Tubal stenosis in gynaecology
2. Dermatological lesions
3. Keloids
4. Hypertrophic scars
5. Localized hypertrophies
6. Inflammatory lesions of lichen
7. Lichen simplex chronicus
8. Granuloma annulare
9. Alopecia areata
10. Necrobiosis lipoidica diabeticorum
11. Discoid lupus erythematosus
12. Psoriatic plaques
Intra-thecal or epidural injections:
1. Lumbago
2. Cervico-brachial neuralgia
3. Sciatica
4. Other painful radiculopathies
5. Multiple sclerosis
6. Tuberculous meningitis.

Interactions for Hydrocortisone

N/A

Typical Dosage for Hydrocortisone

Cream:
Apply 0.5% to 2.5% 1 to 4 times daily as required.
Ointment:
0.5% to 2.5% Apply 1 to 4 times as required.
Lotion:
0.5% to 2.5% Apply 1 to 4 times as required.
Intra-articular, Intra-dermal, Intra-pleural injection:
5 to 50mg depending up on the size of the joint and severity of the condition.

Schedule of Hydrocortisone

Storage Requirements for Hydrocortisone

Store at room temperature at a range of 15 to 300C. Protect from light and moisture. Keep out of reach of children.

Effects of Missed Dosage of Hydrocortisone

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Hydrocortisone

Provide symptomatic treatment and supportive measures.

Tretinoin

About Tretinoin

Retinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.

Mechanism of Action of Tretinoin

Tretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced

Pharmacokinets of Tretinoin

Absorption: Absorption after topical application is minimal.

Onset of Action for Tretinoin

N/A

Duration of Action for Tretinoin

N/A

Half Life of Tretinoin

N/A

Side Effects of Tretinoin

1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema

Contra-indications of Tretinoin

1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn

Special Precautions while taking Tretinoin

1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
NEONATES : Use with caution

Indications for Tretinoin

1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface

Interactions for Tretinoin

Sulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.

Typical Dosage for Tretinoin

Topical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.

Schedule of Tretinoin

Storage Requirements for Tretinoin

Store at 15 - 25 degree C in a tightly closed container.

Effects of Missed Dosage of Tretinoin

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Tretinoin

Give supportive measures and symptomatic treatment.

Home Delivery for Hydroquinone + Hydrocortisone + Tretinoin in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroquinone + hydrocortisone + tretinoin and other medicines and health products. Home delivery services for hydroquinone + hydrocortisone + tretinoin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydroquinone + hydrocortisone + tretinoin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroquinone + hydrocortisone + tretinoin before they complete the sale. You can get this information while placing the order for hydroquinone + hydrocortisone + tretinoin with the pharmacy.

Hydroquinone + Hydrocortisone + Tretinoin is a generic medicine name and there are several brands available for it. Some of the brands for hydroquinone + hydrocortisone + tretinoin might be better known than hydroquinone + hydrocortisone + tretinoin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroquinone + hydrocortisone + tretinoin in stock, you can ask for one of the branded alternatives for hydroquinone + hydrocortisone + tretinoin.