PIMECROLIMUS Pharmacology

PIMECROLIMUS

About PIMECROLIMUS
Immunomodulator, Macrolactam and is a derivative of ascomycin
Mechanism of Action of PIMECROLIMUS
Pimecrolimus binds with high affinity to macrophilin-12 (FKBP-12) and inhibits the calcium-dependent phosphatase, calcineurin. As a consequence, it inhibits T cell activation by blocking the transcription of early cytokines. In particular, pimecrolimus inhibits at nanomolar concentrations Interleukin-2 and interferon gamma (Th1-type) and Interleukin-4 and Interleukin-10 (Th2-type) cytokine synthesis in human T cells. Also, pimecrolimus prevents the release of inflammatory cytokines and mediators from mast cells in vitro after stimulation by antigen/lgE
Pharmacokinets of PIMECROLIMUS
Absorption: Absorbed after topical administration
Distribution: 74-87% bound to plasma proteins
Metabolism: Metabolised in the liver
Excretion: 80% of the drug is excreted in the feces
Onset of Action for PIMECROLIMUS
N/A
Duration of Action for PIMECROLIMUS
N/A
Half Life of PIMECROLIMUS
N/A
Side Effects of PIMECROLIMUS
1.Upper respiratory tract infection
2.Cough
3.Nasopharyngitis and Headache
4.Application-site reactions
Contra-indications of PIMECROLIMUS
Hypersensitivity to the drug
Special Precautions while taking PIMECROLIMUS
1.Renal impairment
2.Hepatic impairment
3.Avoid contact with the eyes and mucous membranes
Pregnancy Related Information
May be used
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
<2 yr: Contraindicated
Indications for PIMECROLIMUS
Atopic dermatitis
Interactions for PIMECROLIMUS
Increased risk of infections when used with live vaccines
Typical Dosage for PIMECROLIMUS
As 1% cream: Apply a thin layer onto the affected areas bid
Schedule of PIMECROLIMUS
N/A
Storage Requirements for PIMECROLIMUS
Store at 15-30?C in a well closed container. Keep out of the reach of child
Effects of Missed Dosage of PIMECROLIMUS
N/A
Effects of Overdose of PIMECROLIMUS
N/A

Home Delivery for PIMECROLIMUS in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pimecrolimus.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pimecrolimus and other medicines and health products. Home delivery services for pimecrolimus may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pimecrolimus only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pimecrolimus before they complete the sale. You can get this information while placing the order for pimecrolimus with the pharmacy.

PIMECROLIMUS is a generic medicine name and there are several brands available for it. Some of the brands for pimecrolimus might be better known than pimecrolimus itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pimecrolimus in stock, you can ask for one of the branded alternatives for pimecrolimus.