Dicyclomine + Simethicone Pharmacology

Dicyclomine + Simethicone

About Dicyclomine + Simethicone
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Mechanism of Action of Dicyclomine + Simethicone
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Pharmacokinets of Dicyclomine + Simethicone
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Onset of Action for Dicyclomine + Simethicone
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Duration of Action for Dicyclomine + Simethicone
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Half Life of Dicyclomine + Simethicone
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Side Effects of Dicyclomine + Simethicone
N/A
Contra-indications of Dicyclomine + Simethicone
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Special Precautions while taking Dicyclomine + Simethicone
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dicyclomine + Simethicone
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Interactions for Dicyclomine + Simethicone
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Typical Dosage for Dicyclomine + Simethicone
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Schedule of Dicyclomine + Simethicone
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Storage Requirements for Dicyclomine + Simethicone
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Effects of Missed Dosage of Dicyclomine + Simethicone
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Effects of Overdose of Dicyclomine + Simethicone
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Dicyclomine

About Dicyclomine
Anticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.
Mechanism of Action of Dicyclomine
Dicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.
Pharmacokinets of Dicyclomine
Absorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine
1-2 hours.
Duration of Action for Dicyclomine
4-6 hours.
Half Life of Dicyclomine
1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))
Side Effects of Dicyclomine
1.Constipation
2.Dry mouth
3.Nausea
4.Vomiting
5.Abdominal discomfort
6.Headache
7.Dizziness
8.Confusion
9.Palpitations
10.Tachycardia
11.Increased intraocular pressure
12.Mydriasis
13.Urine retention
14.Urinary hesitancy
15.Decreased sweating
Contra-indications of Dicyclomine
1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Obstructive uropathy
5.Reflux oesophagitis
6.Severe ulcerative colitis
7.Myasthenia gravis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine
1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Prostatic hypertrophy
5.Hiatus hernia associated
6.Hyperthyroidism
7.Autonomic neuropathy
8.Ulcerative colitis
9.Arrhythmia
10.Hypertension
11.Coronary artery disease
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Dicyclomine
1. Irritable bowel syndrome
2.Colicky pain
Interactions for Dicyclomine
N/A
Typical Dosage for Dicyclomine
Adult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Children:
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of Dicyclomine
H
Storage Requirements for Dicyclomine
Store at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of Dicyclomine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dicyclomine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.

Simethicone

About Simethicone
Oral anti-foaming agent, Silicones, Antiflatulent.
Mechanism of Action of Simethicone
This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.
Pharmacokinets of Simethicone
Excretion- Excreted through feces.
Onset of Action for Simethicone
N/A
Duration of Action for Simethicone
N/A
Half Life of Simethicone
N/A
Side Effects of Simethicone
1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone
1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone
1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Simethicone
1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for Simethicone
N/A
Typical Dosage for Simethicone
Oral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of Simethicone
N/A
Storage Requirements for Simethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Simethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Simethicone
Give symptomatic and supportive treatment.

Home Delivery for Dicyclomine + Simethicone in Your City

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Dicyclomine + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for dicyclomine + simethicone might be better known than dicyclomine + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicyclomine + simethicone in stock, you can ask for one of the branded alternatives for dicyclomine + simethicone.