Ticarcillin Pharmacology

Ticarcillin

About Ticarcillin
Semisynthetic Broad Spectrum Beta Lactam antibiotic,An carboxy Penicillin Derivative.
Mechanism of Action of Ticarcillin
Ticarcillin is bactericidal through inhibition of the final cross-linking stage of peptidoglycan production by binding and inactivating transpeptidases thus inhibiting bacterial cell wall synthesis. It is active against gram-positive bacteria, gram-negative cocci, Pseudomonas aeruginosa, spirochetes, actinomycetes.
Pharmacokinets of Ticarcillin
Absorption: Absorbed after IV administration
Distribution: Widely distibuted. Protein-binding: 50%
Metabolism: Limited metabolism
Excretion: 90% excreted unchanged in urine

Onset of Action for Ticarcillin
N/A
Duration of Action for Ticarcillin
N/A
Half Life of Ticarcillin
1.1 hrs
Side Effects of Ticarcillin
1.Pain at the inj site and phlebitis
2.Electrolyte disturbances
3.Hypersensitivity reactions
4.CNS toxicity including convulsions
5.Severe allergic reactions
6.Diarrhea
7.Headache
8.Nausea
Contra-indications of Ticarcillin
Hypersensitivity to penicillins
Special Precautions while taking Ticarcillin
1.Renal impairment
2.Hepatic impairment
3.Sensitisation
4.Anaphylaxis
5.Cardiac problem
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Ticarcillin
1.Susceptible bacterial septicemia
2.Respiratory or urinary tract infections
3.Skin and soft tissue infections
4.Gynecologic infections
5.Intraabdominal infections
6.Bone and joint infections
Interactions for Ticarcillin
Probenecid decreases clearance of ticarcillin-pottentiate the action
Increased bleeding risk with warfarin, acenocoumarol
Contraceptive failure with combined oral contraceptives
Typical Dosage for Ticarcillin
Severe Gram-negative infections, Skin infections, Septicaemia, Peritonitis,Bone and joint infections
For Adult: 200-300 mg/kg daily by infusion in divided doses every 4 or 6 hr.
For Children: 200-300 mg/kg by infusion in divided doses every 4 or 6 hr

Uncomplicated urinary tract infections:
For adult: 1 g IM/slow IV Injection every 6 hr.
For Children: 50-100 mg/kg in divided doses every 6-8 hr. Do not inject >2 g into each IM site

Complicated urinary tract infections:
For Adult: 150-200 mg/kg daily by IV infusion in divided doses every 4 or 6 h
For Children: 150-200 mg/kg daily by IV infusion in divided doses every 4 or 6 hr
Schedule of Ticarcillin
H
Storage Requirements for Ticarcillin
It should store at temperature below 30 degree C. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Ticarcillin
N/A
Effects of Overdose of Ticarcillin
N/A

Home Delivery for Ticarcillin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ticarcillin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ticarcillin and other medicines and health products. Home delivery services for ticarcillin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ticarcillin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ticarcillin before they complete the sale. You can get this information while placing the order for ticarcillin with the pharmacy.

Ticarcillin is a generic medicine name and there are several brands available for it. Some of the brands for ticarcillin might be better known than ticarcillin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ticarcillin in stock, you can ask for one of the branded alternatives for ticarcillin.