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- Pharmacology For Telmisartan + Amlodipine
Telmisartan + Amlodipine Pharmacology
Telmisartan + Amlodipine
About Telmisartan + AmlodipineN/AMechanism of Action of Telmisartan + AmlodipineN/APharmacokinets of Telmisartan + AmlodipineN/AOnset of Action for Telmisartan + AmlodipineN/ADuration of Action for Telmisartan + AmlodipineN/AHalf Life of Telmisartan + AmlodipineN/ASide Effects of Telmisartan + AmlodipineN/AContra-indications of Telmisartan + AmlodipineN/ASpecial Precautions while taking Telmisartan + AmlodipineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Telmisartan + AmlodipineN/AInteractions for Telmisartan + AmlodipineN/ATypical Dosage for Telmisartan + AmlodipineN/ASchedule of Telmisartan + AmlodipineN/AStorage Requirements for Telmisartan + AmlodipineN/AEffects of Missed Dosage of Telmisartan + AmlodipineN/AEffects of Overdose of Telmisartan + AmlodipineN/ATelmisartan
About TelmisartanAngiotensin II Receptor antagonist, Antihypertensive.Mechanism of Action of TelmisartanIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of TelmisartanAbsorption: Absorbed orally, bioavailability is about 42% Distribution: It is distributed in to the body in a highly protein bound form, Metabolism: Metabolized by glucuronide conjugation in to an inactive metabolite. Excretion: Excreted mainly through faeces and rest is excreted through urine.Onset of Action for TelmisartanN/ADuration of Action for Telmisartan24 hoursHalf Life of Telmisartan24 hoursSide Effects of Telmisartan1.Dizziness
2.Headache
3.Coughing
4.Edema
5.Nausea
6.Abdominal pain
7.Diarrhoea
8.Dyspepsia
9.Pharyngitis
10.Sinusitis
11.Upper respiratory tract infections
12.Urinary tract infections
13.Elevated liver enzymes
14.Weakness
15.Chest pain
16.Myalgia
17.Back pain
18.Neutropenia
19.Fetopathic
20.Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
21.Urticaria
22.Rashes
23.Hyperkalemia
Contra-indications of TelmisartanHypersensitivity to the drugSpecial Precautions while taking Telmisartan1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6.Use cautiously in volume depleted and salt depleted individuals, these conditions should be corrected before starting the therapy
7.Patient should be cautiously involve in driving or operating heavy machinery during therapy
8.Avoid alcohol or use with caution during therapy
9.Use with caution in hyperkalemia and along with potassium sparing diuretics
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Telmisartan1.HypertensionInteractions for TelmisartanN/ATypical Dosage for Telmisartan40mg once daily
Maintenance dose: 20 to 80mg once daily
Schedule of TelmisartanHStorage Requirements for TelmisartanStore at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container. Do not remove blisters until just before taking tablets
Effects of Missed Dosage of TelmisartanTake the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular doseEffects of Overdose of TelmisartanTreatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal salineAmlodipine
About AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
2.Prinzmetal`s angina
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.Home Delivery for Telmisartan + Amlodipine in Your City
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Telmisartan + Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for telmisartan + amlodipine might be better known than telmisartan + amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have telmisartan + amlodipine in stock, you can ask for one of the branded alternatives for telmisartan + amlodipine.