Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone Pharmacology

Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone

About Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Mechanism of Action of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Pharmacokinets of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Onset of Action for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Duration of Action for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Half Life of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Side Effects of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Contra-indications of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Special Precautions while taking Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Interactions for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Typical Dosage for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Schedule of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Storage Requirements for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Effects of Missed Dosage of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A
Effects of Overdose of Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone
N/A

Dicyclomine

About Dicyclomine
Anticholinergic ,Antimuscarinic, Antispasmodic and in urinary incontinence.
Mechanism of Action of Dicyclomine
Dicyclomine is an anticholinergic drug. It exerts its action by inhibiting muscarinic (((cholinergic))) receptors on smooth muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles of gastrointestinal tract and genitourinary tract and reduces the painful spasm and cramp. It inhibits gastrointestinal propulsive motility and reduces gastric acid secretion. It also has a direct relaxant effect on smooth muscle. It readily crosses the blood brain barrier and produces CNS effects.
Pharmacokinets of Dicyclomine
Absorption: About 70 % of the drug is absorbed after oral administration.
Distribution: It is extensively distributed in tissue mainly in protein bound (((99%))) form. It readily crosses blood brain barrier.
Metabolism: Dicyclomine undergoes hepatic metabolism
Excretion: It is excreted mainly in the urine and small amount in the faeces.
Onset of Action for Dicyclomine
1-2 hours.
Duration of Action for Dicyclomine
4-6 hours.
Half Life of Dicyclomine
1.8 hours (((initial phase))). 9 - 10 hours (((secondary phase)))
Side Effects of Dicyclomine
1.Constipation
2.Dry mouth
3.Nausea
4.Vomiting
5.Abdominal discomfort
6.Headache
7.Dizziness
8.Confusion
9.Palpitations
10.Tachycardia
11.Increased intraocular pressure
12.Mydriasis
13.Urine retention
14.Urinary hesitancy
15.Decreased sweating
Contra-indications of Dicyclomine
1.Hypersensitivity to Dicyclomine and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Obstructive uropathy
5.Reflux oesophagitis
6.Severe ulcerative colitis
7.Myasthenia gravis
8.Unstable cardiovascular status in acute haemorrhage
Special Precautions while taking Dicyclomine
1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Prostatic hypertrophy
5.Hiatus hernia associated
6.Hyperthyroidism
7.Autonomic neuropathy
8.Ulcerative colitis
9.Arrhythmia
10.Hypertension
11.Coronary artery disease
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Dicyclomine
1. Irritable bowel syndrome
2.Colicky pain
Interactions for Dicyclomine
N/A
Typical Dosage for Dicyclomine
Adult:
Oral: 80 mg / day in 4 divided doses 30 - 60 minutes before meals. Depending on the patient`s response dose can be increased to 160 mg / day in 4 divided doses after 1 week.
Children:
Infant colic: 5 - 10 mg every 6 - 8 hours, 15 minutes before each feed; dose is depending on the patient`s response and age.
Schedule of Dicyclomine
H
Storage Requirements for Dicyclomine
Store at 15 - 30 degree C in a tightly closed container. Protect from light.Keep out of the reach of children
Effects of Missed Dosage of Dicyclomine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dicyclomine
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Physostigmine is given to block the overdose symptoms of Dicyclomine.

Clidinium Bromide

About Clidinium Bromide
It is a quaternary ammonium compound with anticholingeric properties, Antispasmodics (Systemic).
Mechanism of Action of Clidinium Bromide
Clidinium bromide is an anticholinergic drug. It exerts its action by inhibiting muscarinic cholinergic receptors on smooth muscles, cardiac muscles and prevents the effect of Acetylcholine. Inhibition of Acetylcholine produces relaxation of smooth muscles and prevents the muscle spasm in irritable bowel syndrome.
Pharmacokinets of Clidinium Bromide
Absorption: Clidinium bromide is poorly absorbed about (10 - 25 %) after oral administration.
Distribution:It does not penetrate CNS and eye.
Metabolism: It is extensively metabolised in the small intestine (by hydrolysis) and in the liver to inactive metabolites.
Excretion: Drug and its metabolites are excreted mainly in the urine.
Onset of Action for Clidinium Bromide
60 minute
Duration of Action for Clidinium Bromide
3 hours
Half Life of Clidinium Bromide
N/A
Side Effects of Clidinium Bromide
1.Dry mouth
2.Nausea
3.Vomiting
4.Constipation
5.Muscle weakness
6.Blurred vision
7.Drowsines
Contra-indications of Clidinium Bromide
1.Hypersensitivity to Clidinium bromide and other anticholinergic drugs
2.Narrow angle glaucoma
3.Obstructive gastro intestinal tract
4.Bladder neck obstruction
5.Prostatic hypertrophy
Special Precautions while taking Clidinium Bromide
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular diseases- Hypertension
4.Use caution while performing driving or performing other works requiring mental alertness
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Clidinium Bromide
1.Peptic ulcer
2.Gastritis
3.Irritable bowel syndrome
4.Nervous dyspepsia
Interactions for Clidinium Bromide
Amantadine : Increase in anticholingeric side effects.
Atenolol, Digoxin: Efficacy of atenolol and digoxin enhanced .
Phenothiazines : Decreases antipsychotic activity, and increases anticholingeric activity.
TCAs: Increased anticholinergic side effects ( Dry mouth, constipation, urinary retention)
Typical Dosage for Clidinium Bromide
Adult: 2.5 - 5 mg 3 - 4 times daily before meals and at bed time.
Children: not recommended.
Schedule of Clidinium Bromide
H
Storage Requirements for Clidinium Bromide
Store at below 30 degree C in a tightly closed container. Protect from moisture and sunlight.
Keep out of the reach of children
Effects of Missed Dosage of Clidinium Bromide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clidinium Bromide
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Dimethicone

About Dimethicone
Oral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.
Mechanism of Action of Dimethicone
Activated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of Dimethicone
N/A
Onset of Action for Dimethicone
N/A
Duration of Action for Dimethicone
N/A
Half Life of Dimethicone
N/A
Side Effects of Dimethicone
N/A
Contra-indications of Dimethicone
Hypersensitivity to Dimethicone activated
Special Precautions while taking Dimethicone
Kidney failure
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Dimethicone
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethicone
N/A
Typical Dosage for Dimethicone
125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of Dimethicone
N/A
Storage Requirements for Dimethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Dimethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimethicone
Give symptomatic and supportive treatment.

Home Delivery for Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dicyclomine + clidinium bromide + paracetamol + dimethicone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dicyclomine + clidinium bromide + paracetamol + dimethicone and other medicines and health products. Home delivery services for dicyclomine + clidinium bromide + paracetamol + dimethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dicyclomine + clidinium bromide + paracetamol + dimethicone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dicyclomine + clidinium bromide + paracetamol + dimethicone before they complete the sale. You can get this information while placing the order for dicyclomine + clidinium bromide + paracetamol + dimethicone with the pharmacy.

Dicyclomine + Clidinium bromide + Paracetamol + Dimethicone is a generic medicine name and there are several brands available for it. Some of the brands for dicyclomine + clidinium bromide + paracetamol + dimethicone might be better known than dicyclomine + clidinium bromide + paracetamol + dimethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dicyclomine + clidinium bromide + paracetamol + dimethicone in stock, you can ask for one of the branded alternatives for dicyclomine + clidinium bromide + paracetamol + dimethicone.