Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid Pharmacology

Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid

About Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Mechanism of Action of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Pharmacokinets of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Onset of Action for Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Duration of Action for Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Half Life of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Side Effects of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Contra-indications of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Special Precautions while taking Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Interactions for Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Typical Dosage for Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Schedule of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Storage Requirements for Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Effects of Missed Dosage of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Effects of Overdose of Vitamin E + Eicosapentaenoic Acid + Docosahexenoic Acid
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Vitamin E

About Vitamin E
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Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
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Duration of Action for Vitamin E
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Half Life of Vitamin E
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Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
N/A
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

Eicosapentaenoic Acid

About Eicosapentaenoic Acid
An omega-3 fatty acid, Essential fatty acid, dietary supplement, Anti atherosclerotic.
Mechanism of Action of Eicosapentaenoic Acid
Eicosapentaenoic acid is an omega-3 fatty acid. It is found with Docosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Eicosapentaenoic Acid
N/A
Onset of Action for Eicosapentaenoic Acid
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Duration of Action for Eicosapentaenoic Acid
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Half Life of Eicosapentaenoic Acid
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Side Effects of Eicosapentaenoic Acid
1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.Diarrhoea
Contra-indications of Eicosapentaenoic Acid
Hypersensitivity to the drug
Special Precautions while taking Eicosapentaenoic Acid
1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Infants:Contraindicated
Indications for Eicosapentaenoic Acid
1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Eicosapentaenoic Acid
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Typical Dosage for Eicosapentaenoic Acid
180mg once or twice daily
Schedule of Eicosapentaenoic Acid
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Storage Requirements for Eicosapentaenoic Acid
Store in airtight containers. Protect from light.
Effects of Missed Dosage of Eicosapentaenoic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Eicosapentaenoic Acid
Give supportive measures and symptomatic treatment.

Docosahexenoic Acid

About Docosahexenoic Acid
An omega-3 fatty acid(polyunsaturated fatty acids, PUFAs), An essential fatty acid, brain food ,Antiatherosclerotic.
Mechanism of Action of Docosahexenoic Acid
It is found with Eicosapentaenoic acid. Omega-3 fatty acids are of polyunsaturated fatty acids that derives from food. They help to lower triglycerides and cholesterol and increase HDL cholesterol (the Good cholesterol) and thus improves lipid profile. Omega 3 fatty acids may also act as an anticoagulant to prevent blood clotting. They have anti-inflammatory actions and also lower high blood pressure. The incorporation of Omega-3 fatty acids in the membranes of the cells increases the physicochemical stability and functional integrity. It also makes the cells less susceptible to oxidative damage and also decreases the formation of lipid peroxidases. They protect from cardiovascular disorders and may also reduce the risks and symptoms for other disorders including diabetes, dementia, rheumatoid arthritis, asthma, stroke, inflammatory bowel disease, ulcerative colitis, mental decline, and some cancers. They aid in proper functioning of central nervous system.
Hypolipidaemic action: It produces a reduction in plasma triglycerides by reducing bad cholesterol or very low density lipoproteins.
Antiinflammatory action: Omega - 3 fatty acids are long chain poly unsaturated fatty acids.They compete with arachidonic acid for cyclo-oxygenase and lipoxygenase They inhibits inflammatory mediators by inhibiting leukotriene synthesis pathway.
Antithrombotic effect: They promote vasodilatation, a reduction in platelet aggregation, increased bleeding time and decreased platelet counts
Pharmacokinets of Docosahexenoic Acid
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Onset of Action for Docosahexenoic Acid
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Duration of Action for Docosahexenoic Acid
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Half Life of Docosahexenoic Acid
N/A
Side Effects of Docosahexenoic Acid
1.Loose stools
2.Abdominal discomfort
3.Belching
4.Prolong bleeding time slightly
5.Nausea
6.Vomiting
7.Diarrhoea
8.Constipation
Contra-indications of Docosahexenoic Acid
Hypersensitivity to the drug
Special Precautions while taking Docosahexenoic Acid
1.Haemorrhagic disorders
2.Patient on anticoagulants therapy
3.Hepatic impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Infants: Contraindicated
Indications for Docosahexenoic Acid
1.Coronary artery disease
2.Hypertension
3.Atherosclerosis related disorders
4.Obesity
5.Fatty diet
6.Hyperlipidaemia
7.Smoking
8.Diabetes
Interactions for Docosahexenoic Acid
N/A
Typical Dosage for Docosahexenoic Acid
120 - 240 mg / day in single or 2 divided dose with Eicosapentaenoic acid.
Schedule of Docosahexenoic Acid
N/A
Storage Requirements for Docosahexenoic Acid
Store in airtight containers. Protect from light.
Effects of Missed Dosage of Docosahexenoic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Docosahexenoic Acid
Give supportive measures and symptomatic treatment.

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