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- Pharmacology For Co Enzyme Q10 + Beta Carotene
Co Enzyme Q10 + Beta Carotene Pharmacology
Co Enzyme Q10 + Beta Carotene
About Co Enzyme Q10 + Beta CaroteneN/AMechanism of Action of Co Enzyme Q10 + Beta CaroteneN/APharmacokinets of Co Enzyme Q10 + Beta CaroteneN/AOnset of Action for Co Enzyme Q10 + Beta CaroteneN/ADuration of Action for Co Enzyme Q10 + Beta CaroteneN/AHalf Life of Co Enzyme Q10 + Beta CaroteneN/ASide Effects of Co Enzyme Q10 + Beta CaroteneN/AContra-indications of Co Enzyme Q10 + Beta CaroteneN/ASpecial Precautions while taking Co Enzyme Q10 + Beta CaroteneN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Co Enzyme Q10 + Beta CaroteneAntioxidantInteractions for Co Enzyme Q10 + Beta CaroteneN/ATypical Dosage for Co Enzyme Q10 + Beta Carotene1 capsule / daySchedule of Co Enzyme Q10 + Beta CaroteneN/AStorage Requirements for Co Enzyme Q10 + Beta CaroteneN/AEffects of Missed Dosage of Co Enzyme Q10 + Beta CaroteneN/AEffects of Overdose of Co Enzyme Q10 + Beta CaroteneN/ACo Enzyme Q10
About Co Enzyme Q101,4-benzoquinone derivative, oil-soluble vitamin-like substance, Enzyme cofactors, powerful antioxidantMechanism of Action of Co Enzyme Q10Coenzyme Q10 is vital for the proper transfer of electrons within the mitochondrial oxidative respiratory chain there it passes reducing equivalents to acceptors such as Coenzyme Q: cytochrome c - oxidoreductase:
CoQH2+ 2 FeIII-cytochrome c ? CoQ + 2 FeII-cytochrome c. main function of this transport is adenosine triphosphate production. Coenzyme Q10 also increases adenosine triphosphate levels by preventing the loss of the adenine nucleotide pool from cardiac cells. Coenzyme Q10 has activity as an antioxidant scavenger and an indirect stabilizer of calcium channels to decrease calcium overload. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.
Pharmacokinets of Co Enzyme Q10Absorption- Poorly absorbed after oral administration. Excretion- Excreted through bile and fecesOnset of Action for Co Enzyme Q10N/ADuration of Action for Co Enzyme Q10N/AHalf Life of Co Enzyme Q10N/ASide Effects of Co Enzyme Q101. Nausea
2. Vomiting
3. Stomach upset
4. Heartburn
5. Diarrhea
6. Loss of appetite
7. Skin itching
8. Rash
9. Insomnia
10. Headache
11. Dizziness
12. Irritability
13. Increased light sensitivity of the eyes
14. Fatigue
15. Flu-like symptoms
Contra-indications of Co Enzyme Q10N/ASpecial Precautions while taking Co Enzyme Q10N/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Co Enzyme Q101. Dietary supplement
2. Antioxidant
3. Migraine headaches
4. Parkinson`s Disease
5. Mitochondrial Encephalomyopathies
6. Migraine
7. CHF
8. Hypertension
9. Diabetes
10. Cancer
Interactions for Co Enzyme Q10N/ATypical Dosage for Co Enzyme Q10Adult-
Oral-
Mitochondrial cytopathies: 150 mg per day or 2 mg per kg per day with titration up to 3,000 mg per day in some patients
Parkinson`s disease: 300 to 1,200 mg per day in four divided doses
Cardiovascular problems: 50 to 200 mg per day
Migraine 100 to 200 mg per day
Schedule of Co Enzyme Q10N/AStorage Requirements for Co Enzyme Q10Keep tightly closed in a dry place. Do not expose to excessive heat.Effects of Missed Dosage of Co Enzyme Q10Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of Co Enzyme Q10Give supportive measures and symptomatic treatment.Beta Carotene
About Beta CaroteneA natural precursor to Vitamin A.Mechanism of Action of Beta CaroteneBeta-carotene acts as the precursor of Vitamin A and in the body it is converted in to Vitamin A. Vitamin A is required for a variety of physiological functions in the body such as: - 1).Proper functioning of retina and formation of pigment Rhodopsin during dark adaptation. 2).promotes differentiation and maintains structural integrity of epithelia over the body and also retard the malignancies of epithelial structures.3).Promotes mucous secretion. 4).Inhibits keratinization, 5). Maintains proper bone growth, 6).Maintenance of spermatogenesis, 7).Supports foetal development, 8).Improves resistance to infection. It is required for proper antibody response, normal lymphocyte proliferation and killer cell function.Pharmacokinets of Beta CaroteneAbsorption: Completely absorbed normally. Steatorrhoea, bile deficiency, and protein poor diet adversely affects the absorption and absorption requires bile salts, pancreatic lipase, and dietary fat.
Distribution: Stored primarily as palmitate in kupffer`s cells in liver. Circulates in the form of specific alpha-1 protein; retinol binding protein and transported to cellular retinol binding protein of target cells.
Metabolism: Metabolized in the liver.
Excretion: Excreted mainly through bile and a small amount is excreted through urine.
Onset of Action for Beta CaroteneN/ADuration of Action for Beta CaroteneN/AHalf Life of Beta CaroteneN/ASide Effects of Beta CaroteneAdverse effects occurs only with higher doses and toxicity
1. Nausea
2. Vomiting
3. Itching
4. Dermatitis
5. Exfoliation
6. Alopecia
7. Bone and joint pain
8. Anorexia
9. Irritability
10. Increased intracranial pressure
11. Hepatic impairment
12. Anaphylactic shock
Contra-indications of Beta Carotene1. Hypervitaminosis A
2. Hypersensitivity to Beta Carotene
Special Precautions while taking Beta Carotene1. Oral form should not use in patients with malabsorption syndrome.
2. In inadequate bile secretion oral route may be used with concurrent administration of bile salts.
3. I. V. route is contraindicated except for special water miscible forms intended for infusion with large parenteral volumes and should not use I. V. push of vitamin A of any type.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Beta Carotene1. Vitamin A deficiency
2. Xerophthalmia
3. Acne
4. Ichthyosis
5. Bitot`s spots
6. Night blindness
Interactions for Beta CaroteneCholestyramine: Absorption of Vitamin A is reduced due to reduced availability of fat stabilizing bile salts.
Mineral oil: Interferes with intestinal absorption of Vitamin A.
Oral Contraceptives: Plasma Vitamin A levels are significantly increased.Typical Dosage for Beta CaroteneSevere vitamin A deficiency with xerophthalmia: 500000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Severe vitamin A deficiency: 100000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Children: 5000 to 10000 IU daily for 14 days.
Schedule of Beta CaroteneC1 (Oral)
C (Parenteral)
Storage Requirements for Beta CaroteneStore in a well closed, airtight container in a cool dry place.Effects of Missed Dosage of Beta CaroteneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Beta CaroteneDiscontinue the vitamin A if hypercalcaemia persists and administer I.V. saline, prednisolone, and calcitonin if required. Monitor hepatic function tests to detect liver damage. Home Delivery for Co Enzyme Q10 + Beta Carotene in Your City
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