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- Pharmacology For Alpha-Lipoic acid + Chromium
Alpha-Lipoic acid + Chromium Pharmacology
Alpha-Lipoic acid + Chromium
About Alpha-Lipoic acid + ChromiumN/AMechanism of Action of Alpha-Lipoic acid + ChromiumN/APharmacokinets of Alpha-Lipoic acid + ChromiumN/AOnset of Action for Alpha-Lipoic acid + ChromiumN/ADuration of Action for Alpha-Lipoic acid + ChromiumN/AHalf Life of Alpha-Lipoic acid + ChromiumN/ASide Effects of Alpha-Lipoic acid + ChromiumN/AContra-indications of Alpha-Lipoic acid + ChromiumN/ASpecial Precautions while taking Alpha-Lipoic acid + ChromiumN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Alpha-Lipoic acid + Chromium1.Peripheral neuropathy with antioxidant actionInteractions for Alpha-Lipoic acid + ChromiumN/ATypical Dosage for Alpha-Lipoic acid + ChromiumAdult: 1 capsule to be taken 3 times daily.Schedule of Alpha-Lipoic acid + ChromiumN/AStorage Requirements for Alpha-Lipoic acid + ChromiumN/AEffects of Missed Dosage of Alpha-Lipoic acid + ChromiumN/AEffects of Overdose of Alpha-Lipoic acid + ChromiumN/AAlpha-Lipoic acid
About Alpha-Lipoic acidNaturally occurring dithiol compound , antioxidant, Agent for neuropathies.Mechanism of Action of Alpha-Lipoic acidAlpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.
Pharmacokinets of Alpha-Lipoic acidAbsorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.
Onset of Action for Alpha-Lipoic acidN/ADuration of Action for Alpha-Lipoic acidN/AHalf Life of Alpha-Lipoic acidN/ASide Effects of Alpha-Lipoic acid1.Nausea
2.VomitingContra-indications of Alpha-Lipoic acid1.Contraindicated during radiotherapySpecial Precautions while taking Alpha-Lipoic acidPatient with diabetes and problems with glucose intolerancePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Alpha-Lipoic acid1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disordersInteractions for Alpha-Lipoic acidN/ATypical Dosage for Alpha-Lipoic acidAdult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.Schedule of Alpha-Lipoic acidN/AStorage Requirements for Alpha-Lipoic acidStore at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.Effects of Missed Dosage of Alpha-Lipoic acidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of Alpha-Lipoic acidGive supportive measures and symptomatic treatment.Chromium
About ChromiumChromium is by far the most pivotal nutrient involved in sugar metabolism. Trivalent chromium is a part of glucose tolerance factor, an essential activator of insulin mediated reactions. Chromium improves insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increases in insulin sensitivity. Thus it helps to maintain normal glucose metabolism and peripheral nerve function. A number of clinical studies have been conducted which show that chromium is an effective therapy for both Type I and Type II diabetes. Except for supplementation, there is no good way to rebuild the body?s stockpile of chromium.
Deficiency symptoms: Impaired glucose tolerance, peripheral neuropathy, ataxia, confusion.
Over dosage symptoms: In normal therapeutic doses side effects have not been reported except occasional insomnia. In the event of over dosage - nausea, vomiting, GI ulcers, renal/hepatic damage, convulsion, coma may occur.
Mechanism of Action of ChromiumChromium picolinate acts by influencing carbohydrate metabolism. It stimulates Insulin mediated reactions and improves glucose tolerance. Chromium picolinate helps to improve; insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increase in insulin sensitivity. Thus it maintains normal glucose metabolism and peripheral nerve functions. It improves carbohydrate metabolism, increases energy and helps to control diabetes. It also helps to control weight.Pharmacokinets of ChromiumAbsorption: Well absorbed orally, Distribution: Widely distributed in the body in especially in to liver, kidney, bone, and spleen; normal plasma level is 1 to 5mcg/l. Excretion: Excreted mainly through urine.Onset of Action for ChromiumN/ADuration of Action for ChromiumN/AHalf Life of ChromiumN/ASide Effects of ChromiumN/AContra-indications of Chromium1. Hypersensitivity to the drug.Special Precautions while taking Chromium1. Prolonged therapy with the drug
2.Hypoglycaemia
3.In patients with Type II diabetes mellitus use of chromium picolinate is only under the direct medical supervision
4.Renal impairment
5.Hepatic impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Chromium1.Type I diabetes mellitus
2.Type II diabetes mellitus
3.Obesity.
Interactions for ChromiumN/ATypical Dosage for Chromium Oral: 200 mcg daily; increases up to 1mg daily if required.Schedule of ChromiumN/AStorage Requirements for ChromiumStore in a well closed container at a cool dry place.Effects of Missed Dosage of ChromiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ChromiumGive supportive measures and symptomatic treatment.Home Delivery for Alpha-Lipoic acid + Chromium in Your City
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Alpha-Lipoic acid + Chromium is a generic medicine name and there are several brands available for it. Some of the brands for alpha-lipoic acid + chromium might be better known than alpha-lipoic acid + chromium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have alpha-lipoic acid + chromium in stock, you can ask for one of the branded alternatives for alpha-lipoic acid + chromium.