Colchicine Pharmacology

Colchicine

About Colchicine
N/A
Mechanism of Action of Colchicine
It inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. This tubulin is essential to mitosis, and therefore it inhibits the development of spindles as the nuclei are dividing. These results the death of rapidly proliferating cells. Colchicines in gout reduce lactic acid production by leukocytes, which results in a decrease in uric acid deposition, and it also reduce phagocytosis, with abatement of the inflammatory response.
Pharmacokinets of Colchicine
Absorption- Rapidly absorbed after oral administration.
Distribution- Widely distributed in the body. Do not tightly bind to the plasma proteins. It rapidly enters to the blood stream. It also enters to the breast milk.
Metabolism- Metabolized in liver and tissues to its metabolites.
Excretion- Excretion occurs primarily by biliary and renal routes.
Onset of Action for Colchicine
48 to 72 hrs
Duration of Action for Colchicine
N/A
Half Life of Colchicine
N/A
Side Effects of Colchicine
1. Bone marrow depression
2. Aplastic anemia
3. Agranulocytosis
4. Thrombocytopenia
5. Peripheral neuritis
6. Purpura
7. Myopathy
8. Loss of hair
9. Azoospermia
10. Vomiting
11. Diarrhea
12. Nausea
Contra-indications of Colchicine
1. Hypersensitivity to the drug or any ingredients of it
2. Alcohol abuse
3. Intestinal disease or
4. Stomach ulcer or other stomach problems
5. Heart disease
6. Kidney disease
7. Liver disease
8. Low white blood cell count
9. Low platelet count
Special Precautions while taking Colchicine
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Colchicine
1. Acute gout
2. Gouty arthritis
3. Amyloidosis
4. Beh?et`s syndrome
5. Calcium pyrophosphate deposition disease (pseudogout)
6. Cirrhosis of the liver
7. Familial Mediterranean fever
8. Pericardidtis
9. Sarcoid arthritis
10. Immunosuppressive agent
Interactions for Colchicine
Lab Tests: May cause false positive result while testing urine for haemoglobin or RBCs.
Typical Dosage for Colchicine
Oral-
Adults-
In acute gout - 1mg followed by 0.25mg 1-3 hourly. Maximum: 10mg for an attack. Prophylaxis: 0.5-1.5 mg/day.
Amyloidosis- 500 to 600mcg one to two times daily.
Cirrhosis of the liver - 1mg for 5 days weekly.
Familial Mediterranean fever - 1 to 2mg/day in divided doses.
Schedule of Colchicine
H
Storage Requirements for Colchicine
Store away from heat and direct light. Keep out of the reach of children.
Effects of Missed Dosage of Colchicine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Colchicine
Give symptomatic and supportive treatment. Induce gastric lavage. Provide haemodialysis and peritoneal dialysis if needed. Administer atropine or morphine to relieve the pain and paregoric to prevent diarrhea and cramps.

Home Delivery for Colchicine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including colchicine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for colchicine and other medicines and health products. Home delivery services for colchicine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take colchicine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for colchicine before they complete the sale. You can get this information while placing the order for colchicine with the pharmacy.

Colchicine is a generic medicine name and there are several brands available for it. Some of the brands for colchicine might be better known than colchicine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have colchicine in stock, you can ask for one of the branded alternatives for colchicine.