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- Pharmacology For Iron (Ferrous glycine sulphate) + Folic acid + Zinc
Iron (Ferrous glycine sulphate) + Folic acid + Zinc Pharmacology
Iron (Ferrous glycine sulphate) + Folic acid + Zinc
About Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AMechanism of Action of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/APharmacokinets of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AOnset of Action for Iron (Ferrous glycine sulphate) + Folic acid + ZincN/ADuration of Action for Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AHalf Life of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/ASide Effects of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AContra-indications of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/ASpecial Precautions while taking Iron (Ferrous glycine sulphate) + Folic acid + ZincN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AInteractions for Iron (Ferrous glycine sulphate) + Folic acid + ZincN/ATypical Dosage for Iron (Ferrous glycine sulphate) + Folic acid + ZincN/ASchedule of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AStorage Requirements for Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AEffects of Missed Dosage of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AEffects of Overdose of Iron (Ferrous glycine sulphate) + Folic acid + ZincN/AIron (Ferrous glycine sulphate)
About Iron (Ferrous glycine sulphate)Oral iron preparation, An iron-containing salt, Antianemic,hematinicMechanism of Action of Iron (Ferrous glycine sulphate)Ferrous glycine sulfate is a chelate of ferrous sulfate and glycine used as a source of iron for iron-deficiency anaemia. It is given by mouth in doses containing the equivalent of up to 150 mg of iron daily. It exerts haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.
It has relatively high bioavailability in the presence of dietary inhibitors. Chelates prevent iron from binding to inhibitors in food or precipitating as insoluble ferric hydroxide in the pH of the small intestine.
Pharmacokinets of Iron (Ferrous glycine sulphate)Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.Onset of Action for Iron (Ferrous glycine sulphate)N/ADuration of Action for Iron (Ferrous glycine sulphate)N/AHalf Life of Iron (Ferrous glycine sulphate)N/ASide Effects of Iron (Ferrous glycine sulphate)1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations
Contra-indications of Iron (Ferrous glycine sulphate)1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions.
Special Precautions while taking Iron (Ferrous glycine sulphate)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Ferrous glycine sulphate)1. Iron deficiency
2. Iron deficiency anaemiaInteractions for Iron (Ferrous glycine sulphate)N/ATypical Dosage for Iron (Ferrous glycine sulphate)Adult: I capsule or 10ml once or twice daily after meals.
Children: 5-10 ml twice daily after meals.
Schedule of Iron (Ferrous glycine sulphate)N/AStorage Requirements for Iron (Ferrous glycine sulphate)Store in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Iron (Ferrous glycine sulphate)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Ferrous glycine sulphate)Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl.Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Zinc
About ZincTrance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.Mechanism of Action of ZincZinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.Pharmacokinets of ZincAbsorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.Onset of Action for ZincN/ADuration of Action for ZincN/AHalf Life of ZincN/ASide Effects of Zinc1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes
Contra-indications of ZincN/ASpecial Precautions while taking Zinc1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia
Interactions for ZincFluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.
Typical Dosage for ZincAdults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of ZincN/AStorage Requirements for ZincStore at a temperature below 30 degree CEffects of Missed Dosage of ZincTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ZincProvide symptomatic treatment and supportive measuresHome Delivery for Iron (Ferrous glycine sulphate) + Folic acid + Zinc in Your City
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