Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract Pharmacology

Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract

About Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Mechanism of Action of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Pharmacokinets of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Onset of Action for Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Duration of Action for Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Half Life of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Side Effects of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Contra-indications of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Special Precautions while taking Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Interactions for Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Typical Dosage for Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Schedule of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Storage Requirements for Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Effects of Missed Dosage of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Effects of Overdose of Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract
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Vit B1

About Vit B1

Physiological functions: Thiamine pyrophosphate is a coenzyme and the active form of vitamin B. It functions as coenzyme in decarboxylation of a-keto acid and in Hexose Monophosphate shunt.
Deficiency symptoms: In severe vitamin B1 deficiency beriberi develops. It is of two types:
a) Wet beriberi
b) Dry beriberi
Wet beriberi: In this the symptoms are related to the cardiovascular system and they are palpitations, tachycardia, dyspnoea, ECG changes, oedema, and high output cardiac failure.
Dry beriberi: The symptoms and signs are related to the Nervous system. The main features are peripheral neuritis, hyperaesthesia (localized areas) or anaesthesia, there is gradual loss in muscle strength, wrist drop, poor memory, depression, lack of initiative and anorexia.
Mechanism of Action of Vit B1
Thiamine exerts it`s action by influencing carbohydrate metabolism. It combines with ATP to form thiamine pyrophosphate in the body. Thiamine pyrophosphate acts as a coenzyme for carbohydrate metabolism, decarboxylation of ketoacids, and hexose monophosphate shunt. It also have plays some role in neuromuscular transmission.
Pharmacokinets of Vit B1
Absorption: Well absorbed orally.
Distribution: Widely distributed in the body. It is also distributed in to breast milk.
Metabolism: Metabolized in the liver.
Excretion: Excess thiamine is excreted through urine.
Onset of Action for Vit B1
N/A
Duration of Action for Vit B1
N/A
Half Life of Vit B1
N/A
Side Effects of Vit B1
1. Angioedema
2. Cardiovascular collapse
3. Cyanosis
4. Restleessness
5. Nausea
6. Haemorrhage
7. Weakness
8. Allergic reactions
9. Tightness of throat
10. Feeling of warmth
11. Urticaria
12. Pruritus
13. Tenderness and induration following I. M. administration
Contra-indications of Vit B1
1. Hypersensitivity to the drug
Special Precautions while taking Vit B1
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Vit B1
1. Thiamine deficiency
2. Dry beriberi
3. Wet beriberi
4. Wernicke`s encephalopathy
5. Hyperemesis gravidarum
6. Korsakoffs syndrome
7. Polyneuritis secondary to alcoholism
8. Multiple neurosis
9. Toxic and confusional states
10. Anorexia nervosa
11. Delirium
Interactions for Vit B1
N/A
Typical Dosage for Vit B1
Oral :
In mild deficiency: 10 to 25mg/day.
In severe deficiency: 200 to 300mg/day.
I.M, I.V.:
Beriberi:
Adults: 10 to 20mg I.M. depending up on the severity of the condition (Up to 100mg I.M. or I.V. for severe cases); thrice daily for two weeks followed by dietary correction and multivitamin supplement containing 5 to 30mg Thiamine/day in single or divided doses for 1 month.
Wernicke`s encephalopathy: 100mg I.V. followed by 50 to 100mg IM. or I.V./day.
"Wet beriberi with heart failure": 10 to 30mg I.V. for emergency treatment.

Schedule of Vit B1
C1 (Oral)
Storage Requirements for Vit B1
Store in a well closed container; in a cool place and protect from light.
Effects of Missed Dosage of Vit B1
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B1
Provide symptomatic treatment and supportive measures.

Vit B2

About Vit B2
N/A
Mechanism of Action of Vit B2
Riboflavin exerts it`s action by influencing metabolic reactions. Riboflavin functions in the forms of flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) which are coenzymes for flavoproteins involved in many oxidation-reduction reactions. Both FMN and FAD play a vital metabolic role in numerous tissue respiration systems. Riboflavin also directly involves in maintaining erythrocyte integrity.
Pharmacokinets of Vit B2
Absorption: Well absorbed orally; bioavailability increases when administer along with food.
Distribution: Widely distributed in the tissues and limited amount is stored in the liver, spleen, kidneys, and heart. It crosses the placenta and also secreted in to the breast milk.
Metabolism: Phosphorylated in the intestine, liver and other tissues to FMN and metabolized in to FAD the liver.
Excretion: Larger doses are excreted unchanged in urine.
Onset of Action for Vit B2
N/A
Duration of Action for Vit B2
N/A
Half Life of Vit B2
66 to 84 minutes
Side Effects of Vit B2
1. Bright yellow urine with higher doses
Contra-indications of Vit B2
No known contraindications.
Special Precautions while taking Vit B2
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Vit B2
1. Ariboflavinosis
2. Arteriosclerosis
3. Hypertension
4. Obesity
5. Diabetis
6. Cholepathy
7. Glossitis
8. Stomatitis
9. Dermatitis of trunk and extremities
10. Other riboflavin deficiency symptoms
Interactions for Vit B2
Oral contraceptive:Dose of Riboflavin may need to be increased
Propantheline Bromide:Delays absorption rate of Riboflavin
Typical Dosage for Vit B2
Oral:
Adults: 20 to 40mg three times daily or depending up on the severity.
Children: 20mg daily.
Riboflavin deficiency:
Adults and children over 12 years: 5 to 30mg/day depending up on the severity .
Children (below 12years): 3 to 10mg/day depending up on the severity.
Schedule of Vit B2
C1
Storage Requirements for Vit B2
Store in a well closed container; in a cool place and protect from light.
Effects of Missed Dosage of Vit B2
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Vit B2
Provide symptomatic treatment and supportive measures.

Vit B3

About Vit B3
N/A
Mechanism of Action of Vit B3
Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and it`s phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Vit B3
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Vit B3
N/A
Duration of Action for Vit B3
N/A
Half Life of Vit B3
N/A
Side Effects of Vit B3
1. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Vit B3
1. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Vit B3
1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of Statins
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Vit B3
1. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)
Interactions for Vit B3
Aspirin: May decrease the metabolic clearance of nicotinic acid
Sympathetic blocking agent: May cause added vasodilation and hypotension
Isoniazid: may deplete levels of niacin and cause deficiency.
Typical Dosage for Vit B3
Oral:
Pellagra: 200 to 500mg daily in divided doses
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Peripheral vascular diseases (only nicotinic acid): 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia (only nicotinic acid): 1.5 to 6g daily in two to four divided doses with or after meals.
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Vit B3
C1
Storage Requirements for Vit B3
Store at controlled room temperature at a range of 15 to 30 degree C
Effects of Missed Dosage of Vit B3
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B3
Provide supportive measures and symptomatic treatment

Vit B5

About Vit B5
Vitamin , A water-soluble B complex vitamin.
Mechanism of Action of Vit B5
Pantothenic acid exerts it`s actions by influencing metabolic reactions. It is a component of coenzyme-A which functions in carbohydrate, fat, steroid and porphyrin metabolism by catalyzing acetate transfer reactions.
Pharmacokinets of Vit B5
Absorption: Well absorbed orally.
Distribution: Widely distributed in the body tissues, and appears in the breast milk.
Excretion: 70% excreted unchanged in urine and 30% in faeces.
Onset of Action for Vit B5
N/A
Duration of Action for Vit B5
N/A
Half Life of Vit B5
N/A
Side Effects of Vit B5
N/A
Contra-indications of Vit B5
N/A
Special Precautions while taking Vit B5
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Vit B5
1. Nutritional supplement in conjunction with other B vitamins
2. Post operative paralytic ileus.
Interactions for Vit B5
Tetracycline: Vitamin B5 should not be taken at the same time as the Tetracycline because it interferes with the absorption and effectiveness of this medication.
B vitamins should be taken at different times from tetracycline.
Typical Dosage for Vit B5
Oral: 50 to 100mg daily.
Schedule of Vit B5
C1
Storage Requirements for Vit B5
Store in a well closed container; in a cool place and protect from light.
Effects of Missed Dosage of Vit B5
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B5
Provide symptomatic treatment and supportive measures.

Vit B6

About Vit B6
Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.
Mechanism of Action of Vit B6
Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.
Pharmacokinets of Vit B6
Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6
N/A
Duration of Action for Vit B6
N/A
Half Life of Vit B6
15-20 days
Side Effects of Vit B6
1. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B6
1. Hypersensitivity to Vitamin B6
Special Precautions while taking Vit B6
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Vit B6
1. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6
Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6
Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6
N/A
Storage Requirements for Vit B6
Store it at 15 - 30 degree C. Protect from moisture and heat.
Effects of Missed Dosage of Vit B6
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B6
Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.

Vitamin E

About Vitamin E
N/A
Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
N/A
Duration of Action for Vitamin E
N/A
Half Life of Vitamin E
N/A
Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
N/A
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

Thyroid Extract

About Thyroid Extract
Extracts derived from the thyroid glands(bovine), Nutritional supplement.
Mechanism of Action of Thyroid Extract
N/A
Pharmacokinets of Thyroid Extract
N/A
Onset of Action for Thyroid Extract
N/A
Duration of Action for Thyroid Extract
N/A
Half Life of Thyroid Extract
N/A
Side Effects of Thyroid Extract
No side effects
Contra-indications of Thyroid Extract
N/A
Special Precautions while taking Thyroid Extract
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Thyroid Extract
1. Hypothyroidism
Interactions for Thyroid Extract
N/A
Typical Dosage for Thyroid Extract
Depends on the concentration, method of preparation, and quality of the thyroid extract dose is determined by the Physician.
Schedule of Thyroid Extract
N/A
Storage Requirements for Thyroid Extract
N/A
Effects of Missed Dosage of Thyroid Extract
N/A
Effects of Overdose of Thyroid Extract
N/A

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Vit B1 + Vit B2 + Vit B3 + Vit B5 + Vit B6 + Vitamin E + Thyroid Extract is a generic medicine name and there are several brands available for it. Some of the brands for vit b1 + vit b2 + vit b3 + vit b5 + vit b6 + vitamin e + thyroid extract might be better known than vit b1 + vit b2 + vit b3 + vit b5 + vit b6 + vitamin e + thyroid extract itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vit b1 + vit b2 + vit b3 + vit b5 + vit b6 + vitamin e + thyroid extract in stock, you can ask for one of the branded alternatives for vit b1 + vit b2 + vit b3 + vit b5 + vit b6 + vitamin e + thyroid extract.