Vit B12 + Biotin Pharmacology

Vit B12 + Biotin

About Vit B12 + Biotin
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Mechanism of Action of Vit B12 + Biotin
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Pharmacokinets of Vit B12 + Biotin
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Onset of Action for Vit B12 + Biotin
N/A
Duration of Action for Vit B12 + Biotin
N/A
Half Life of Vit B12 + Biotin
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Side Effects of Vit B12 + Biotin
N/A
Contra-indications of Vit B12 + Biotin
N/A
Special Precautions while taking Vit B12 + Biotin
N/A
Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Vit B12 + Biotin
N/A
Interactions for Vit B12 + Biotin
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Typical Dosage for Vit B12 + Biotin
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Schedule of Vit B12 + Biotin
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Storage Requirements for Vit B12 + Biotin
N/A
Effects of Missed Dosage of Vit B12 + Biotin
N/A
Effects of Overdose of Vit B12 + Biotin
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Vit B12

About Vit B12
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Mechanism of Action of Vit B12
Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.
Pharmacokinets of Vit B12
Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12
N/A
Duration of Action for Vit B12
N/A
Half Life of Vit B12
N/A
Side Effects of Vit B12
1. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B12
1. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B12
1. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
NEONATES : Use with caution
Indications for Vit B12
1. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12
N/A
Typical Dosage for Vit B12
I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12
C
Storage Requirements for Vit B12
Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.
Effects of Missed Dosage of Vit B12
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B12
Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.

Biotin

About Biotin
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Mechanism of Action of Biotin
Biotin excerts it`s pharmacological action by influencing metabolic reactions. It acts as a coenzyme for carbohydrate, fat, and protein metabolism. It is required for cell growth and production of fatty acids. It is required for healthy maintenance of hair, skin, sweat glands, nerve tissue, and bone marrow. It also helps in the transfer of carbon dioxide and in the maintenance of a steady blood sugar level.
Pharmacokinets of Biotin
Absorption: Well absorbed orally, Excretion: Extra drug is excreted unchanged in urine.
Onset of Action for Biotin
N/A
Duration of Action for Biotin
N/A
Half Life of Biotin
N/A
Side Effects of Biotin
N/A
Contra-indications of Biotin
Hypersensitivity of any biotin products.
Special Precautions while taking Biotin
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Biotin
1.Biotin deficiency
2 Alopecia
3.Brittle nails
4.Prevent diabetic neuropathy and lower blood glucose levels in diabetic patients
5.Seborrheic dermatitis
6.Dry skin.
Interactions for Biotin
N/A
Typical Dosage for Biotin
Oral: 30 to 70mcg daily. Increased up to 300mcg/day if required based on the severity of deficiency.
Pregnancy: 30mcg daily
Lactation: 35mcg daily
Prevent brittle nails: 2.5mg/day.
Schedule of Biotin
C1
Storage Requirements for Biotin
Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.
Effects of Missed Dosage of Biotin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Biotin
Provide symptomatic treatment and supportive measures.

Home Delivery for Vit B12 + Biotin in Your City

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Vit B12 + Biotin is a generic medicine name and there are several brands available for it. Some of the brands for vit b12 + biotin might be better known than vit b12 + biotin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vit b12 + biotin in stock, you can ask for one of the branded alternatives for vit b12 + biotin.