Rituximab Pharmacology

Rituximab

About Rituximab
Monoclonal IgG1 kappa Antibody, Antineoplastic.
Mechanism of Action of Rituximab
Rituximab is a chimeric monoclonal antibody. It is active against the CD20 antigen found on the surface of normal and malignant B lymphocytes.
Monoclonal antibodies are used to destroy tumour cells. They recognise certain proteins that are found on the surface of particular cancer cells. The monoclonal antibody recognises the protein and binds onto it. This may then trigger the body`s immune system to attack the cancer cells and can cause the cells to destroy themselves.Similarly Rituximab binds onto CD20 protein on the surface of the normal and malignant white blood cells (B-cell lymphocytes).The body quickly replaces normal white blood cells which are damaged, so side effects are very small. Rituximab is also used in the treatment of Rheumatoid arthritis.
Pharmacokinets of Rituximab
Absorption:It is completely absorbed after parenteral administration.
Onset of Action for Rituximab
N/A
Duration of Action for Rituximab
N/A
Half Life of Rituximab
N/A
Side Effects of Rituximab
1.Fever
2.Chills
3.Infection
4.Asthenia
5.Headache
6.Nausea
7.Diarrhea
8.Vomiting
9.Abdominal Pain
10.Throat Irritation
11.Flushing
12.Hypotension
13.Hypertension
14.Lymphopenia
15.Leukopenia
16.Neutropenia
17.Thrombocytopenia
18.Anemia
19.Hyperglycemia
20.Edema
21.Myalgia
22.Arthralgia
23.Dizziness
24.Anxiety
25.Cough
26.Rhinitis
27.Bronchospasm
28.Dyspnea
29.Sinusitis
30.Night Sweats
31.Rash
32.Pruritus
33.Urticaria
Contra-indications of Rituximab
N/A
Special Precautions while taking Rituximab
Pulmonary dysfunction
Pregnancy Related Information
N/A
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Rituximab
1.Non-Hodgkin`s Lymphoma
2.Rheumatoid arthritis
Interactions for Rituximab
N/A
Typical Dosage for Rituximab
Adult: 375 mg/m? IV infusion once weekly for 4 or 8 doses
Rheumatoid Arthritis: Rituximab is given as 1g IV infusions on day 1 and repeated on 14th day.
Schedule of Rituximab
N/A
Storage Requirements for Rituximab
Store at 2 - 8 degree Celsius. Do not freeze. Keep out of the reach of children
Effects of Missed Dosage of Rituximab
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Rituximab
Give supportive measures and symptomatic treatment.

Home Delivery for Rituximab in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including rituximab.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for rituximab and other medicines and health products. Home delivery services for rituximab may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take rituximab only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for rituximab before they complete the sale. You can get this information while placing the order for rituximab with the pharmacy.

Rituximab is a generic medicine name and there are several brands available for it. Some of the brands for rituximab might be better known than rituximab itself. If the pharmacy that's willing to deliver medicines to your home doesn't have rituximab in stock, you can ask for one of the branded alternatives for rituximab.