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- Pharmacology For Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)
Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops) Pharmacology
Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)
About Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AMechanism of Action of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/APharmacokinets of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AOnset of Action for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ADuration of Action for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AHalf Life of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ASide Effects of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AContra-indications of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ASpecial Precautions while taking Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/APregnancy Related InformationContraindicated; since Chloramphenicol is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Chloramphenicol is contraindicated in breast feeding, the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)1.Fungal infection of ear (otitis externa)Interactions for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ATypical Dosage for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)Apply 2 -3 drop in to the ear 2 - 3 times daily.Schedule of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AStorage Requirements for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AEffects of Missed Dosage of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AEffects of Overdose of Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ABeclomethasone dipropionate
About Beclomethasone dipropionatePotent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.Mechanism of Action of Beclomethasone dipropionateMechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Beclomethasone dipropionateAbsorption: It enters in to the systemic circulation after topical administration.Onset of Action for Beclomethasone dipropionateN/ADuration of Action for Beclomethasone dipropionateN/AHalf Life of Beclomethasone dipropionateN/ASide Effects of Beclomethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Beclomethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionateThere are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionateTopical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected areaSchedule of Beclomethasone dipropionateHStorage Requirements for Beclomethasone dipropionateStore below 25 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of Beclomethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Beclomethasone dipropionateGive supportive measures and symptomatic treatment.Chloramphenicol (Eye/Ear Drops)
About Chloramphenicol (Eye/Ear Drops)Bacteriostatic broad-spectrum antibiotic, ophthalmic antibacterial agent for ocular infections.Mechanism of Action of Chloramphenicol (Eye/Ear Drops)Chloramphenicol is a broad spectrum antibiotic which is primarily bacteriostatic at low concentration and exerts bactericidal action at higher concentration. It acts by inhibiting bacterial protein synthesis. Chloramphenicol attaches to 50S subunit of ribosome and interfering with transfer of elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome-m RNA complex. It prevents the access of aminoacyl-tRNA to the acceptor site for amino acid incorporation. By acting as a peptide analogue it inhibits peptide bond formation.
Chloramphenicol eye/ear drops or eye ointment which are applied to the eye/ear directly act on the bacteria which produces infection.
Pharmacokinets of Chloramphenicol (Eye/Ear Drops)Absorption: Only a very small amount of the drug enters in to the systemic circulation:Onset of Action for Chloramphenicol (Eye/Ear Drops)N/ADuration of Action for Chloramphenicol (Eye/Ear Drops)N/AHalf Life of Chloramphenicol (Eye/Ear Drops)N/ASide Effects of Chloramphenicol (Eye/Ear Drops)1.Burning
2.Stinging
3.Hypersensitivity reactions( Anaphylaxis, Angioneurotic edema, Urticaria, Fever, Vesicular and maculopapular dermatitis)Contra-indications of Chloramphenicol (Eye/Ear Drops)1.Hypersensitivity to Chloramphenicol
2.Myelosuppression during previous exposure to Chloramphenicol
3.Blood dyscrasias
4.Perforated ear drum (ear drops)Special Precautions while taking Chloramphenicol (Eye/Ear Drops)1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Avoid driving vehicle or operating machine since Chloramphenicol eye drops produces blurred vision
5.If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments lastPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 2 years: contraindicatedIndications for Chloramphenicol (Eye/Ear Drops)EYE DROPS:
1.Bacterial conjunctivitis
2.Corneal ulcers
3.Trachoma
4.Ocular infections
EAR DROPS:
1.Bacterial Otitis externa
2.Chronic Otitis media
3.Pre and post aural or mastoid surgery
Interactions for Chloramphenicol (Eye/Ear Drops)N/ATypical Dosage for Chloramphenicol (Eye/Ear Drops)Chloramphenicol eye drops 0.4%, 0.5% and 1% and eye ointments 1% w/v is available.
Eyes: 1 drop should be instilled in the infected eye every 2 hours for 2 days and thereafter every 4 hours for up to 5 days. Do not use during sleep.
Chloramphenicol 5% w/v drop is used
Ears: The area should be cleaned and 2 - 3 drops instilled in the infected ear 3 - 4 times a day for up to 1 week
Children: 1 - 2 drops 3 times daily.
Schedule of Chloramphenicol (Eye/Ear Drops)N/AStorage Requirements for Chloramphenicol (Eye/Ear Drops)Stored in a refrigerator at 2? to 8?C.Protect from heat and light. Opened eye drops should be discarded after 5 days. Keep out of the reach of childrenEffects of Missed Dosage of Chloramphenicol (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chloramphenicol (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Clotrimazole (Ear Drops)
About Clotrimazole (Ear Drops)A broad-spectrum antifungal antibiotic, imidazole derivative, Antifungal in otitis externa and otomycoses.Mechanism of Action of Clotrimazole (Ear Drops)Clotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis. This will alter the membrane permeability of the susceptible fungusPharmacokinets of Clotrimazole (Ear Drops)N/AOnset of Action for Clotrimazole (Ear Drops)N/ADuration of Action for Clotrimazole (Ear Drops)N/AHalf Life of Clotrimazole (Ear Drops)N/ASide Effects of Clotrimazole (Ear Drops)1.Local irritationContra-indications of Clotrimazole (Ear Drops)Perforation of tympanic membrane.Special Precautions while taking Clotrimazole (Ear Drops)1. Not for ophthalmic use
2. HypersensitivityPregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Clotrimazole (Ear Drops)1. Fungal infections of Otitis externaInteractions for Clotrimazole (Ear Drops)N/ATypical Dosage for Clotrimazole (Ear Drops)Ear drops: 1%w/v Clotrimazole solution is used.
Adult: Instill 2 - 3 drops 6- 8 hourly for 2 weeks.
Schedule of Clotrimazole (Ear Drops)N/AStorage Requirements for Clotrimazole (Ear Drops)Store at cool dry place. Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Clotrimazole (Ear Drops)Instill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clotrimazole (Ear Drops)Give supportive measures and symptomatic treatment. Home Delivery for Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops) in Your City
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Beclomethasone dipropionate + Chloramphenicol (Eye/Ear Drops)+ Clotrimazole (Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate + chloramphenicol (eye/ear drops)+ clotrimazole (ear drops) might be better known than beclomethasone dipropionate + chloramphenicol (eye/ear drops)+ clotrimazole (ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate + chloramphenicol (eye/ear drops)+ clotrimazole (ear drops) in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate + chloramphenicol (eye/ear drops)+ clotrimazole (ear drops).