Norfloxacin (E/E) Pharmacology

Norfloxacin (E/E)

About Norfloxacin (E/E)
A synthetic second generation synthetic fluoroquinolone (quinolone), Ophthalmic antibiotc.
Mechanism of Action of Norfloxacin (E/E)
Norfloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Norfloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Norfloxacin (E/E)
Absorption: Absorption after ophthalmic application is minimal
Onset of Action for Norfloxacin (E/E)
N/A
Duration of Action for Norfloxacin (E/E)
N/A
Half Life of Norfloxacin (E/E)
N/A
Side Effects of Norfloxacin (E/E)
1. Burning
2. Irritation
3. Itching
4. Bitter taste
5. Blurred vision
6. Increased sensitivity of the eyes to light
7. Redness
8. Swelling
9. Pain
Contra-indications of Norfloxacin (E/E)
1. Hypersensitivity to Norfloxacin and other Fluoroquinolones
2. Not use injection or subconjunctivally in to the eye
Special Precautions while taking Norfloxacin (E/E)
1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
4. Wear sun glasses if sensitivity to sunlight occurs
5. Avoid driving vehicle since it causes blurred vision
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Norfloxacin (E/E)
1.Otitis externa
2.Acute otitis media
3.Prophylaxis during otic surgeries such as mastoid surgery
Interactions for Norfloxacin (E/E)
N/A
Typical Dosage for Norfloxacin (E/E)
Ear drops:
3 to 5 drops every 3 hours
Schedule of Norfloxacin (E/E)
N/A
Storage Requirements for Norfloxacin (E/E)
Store at cool dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.
Effects of Missed Dosage of Norfloxacin (E/E)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Norfloxacin (E/E)
Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.

Home Delivery for Norfloxacin (E/E) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including norfloxacin (e/e).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for norfloxacin (e/e) and other medicines and health products. Home delivery services for norfloxacin (e/e) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take norfloxacin (e/e) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for norfloxacin (e/e) before they complete the sale. You can get this information while placing the order for norfloxacin (e/e) with the pharmacy.

Norfloxacin (E/E) is a generic medicine name and there are several brands available for it. Some of the brands for norfloxacin (e/e) might be better known than norfloxacin (e/e) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have norfloxacin (e/e) in stock, you can ask for one of the branded alternatives for norfloxacin (e/e).