Calcipotriol Pharmacology

Calcipotriol

About Calcipotriol
It is a new vitamin D analogue. Non-steroidal Antipsoriatic.
Mechanism of Action of Calcipotriol
Calcipotriol is a vitamin D analogue. It is a non-steroidal anti-psoriatic agent. Since it is a vitamin-D analogue it competes for 1, 25 (OH)2 D3 receptor. Calcipotriol is as potent as 1, 25 Dihydroxy cholecalciferol and regulating cell proliferation and cell differentiation, but much less active than Dihydroxy cholecalciferol in its effect on calcium metabolism. Calcipotriol induces keratinocytes differentiation and suppresses proliferation. Thus it reverses the abnormal keratinocytes changes in psoriasis and also normalizes epidermal growth. . When applied to the skin it works by reducing the production of skin cells. In psoriasis, the scaling and thickening of the skin and the appearance of raised plaques, are the result of excessive skin cell production. Calcipotriol reduces the excessive skin cell production and therefore helps improve the symptoms of psoriasis.
Calcipotriol is used to treat plaque psoriasis: Plaque psoriasis is a skin disorder caused by rapid multiplication of cells in the outer layer of the skin. As new skin cells are produced, old ones are shed. If this process is taking place too quickly, old skin cells build up on the skin surface causing red, scaly patches. Calcipotriol helps to control psoriasis by slowing down the production of new skin cells.
Pharmacokinets of Calcipotriol
Absorption: About 5 - 6 % drug is absorbed after topical application.
Onset of Action for Calcipotriol
N/A
Duration of Action for Calcipotriol
N/A
Half Life of Calcipotriol
N/A
Side Effects of Calcipotriol
1.Local irritation
2.Photosnsitivity
3.Burning
4.Pruritis
5.Atrophy
6.Dermatitis
7.Dryness of the skin
8.Hyperpigmentation
9.Folliculitis
10.Erythema
11.Peeling
12. Rashes
Contra-indications of Calcipotriol
1. Hypersensitivity to Calcipotriol
2.Hypercalcaemia
3.Hypercalciuria
4.Hypervitaminosis D
5.Nephrolithiasis
6.Severe extensive psoriasis

Special Precautions while taking Calcipotriol
1.If irritation occurs discontinue the use of medicaments
2.Avoid use on face and eyes
3.Avoid exposure to sunlight
4.For external use only
5.Excessive prolonged use
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Contraindicated
Indications for Calcipotriol
Chronic stable plaque type psoriasis in adults.
Interactions for Calcipotriol
N/A
Typical Dosage for Calcipotriol
Topical: 0.005%w/w Calcipotriol is used.
Apply as thin layer to the affected area with gentle massage 2 times daily
Wash hands before and after application
Schedule of Calcipotriol
H
Storage Requirements for Calcipotriol
Store in a cool dry place away from heat and direct sunlight. Keep out of the reach of children
Effects of Missed Dosage of Calcipotriol
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Calcipotriol
Give supportive measures and symptomatic treatment

Home Delivery for Calcipotriol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including calcipotriol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for calcipotriol and other medicines and health products. Home delivery services for calcipotriol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take calcipotriol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for calcipotriol before they complete the sale. You can get this information while placing the order for calcipotriol with the pharmacy.

Calcipotriol is a generic medicine name and there are several brands available for it. Some of the brands for calcipotriol might be better known than calcipotriol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcipotriol in stock, you can ask for one of the branded alternatives for calcipotriol.