Fluocinolone acetonide + Salicylic acid + Benzoic acid Pharmacology

Fluocinolone acetonide + Salicylic acid + Benzoic acid

About Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Mechanism of Action of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Pharmacokinets of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Onset of Action for Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Duration of Action for Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Half Life of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Side Effects of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Contra-indications of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Special Precautions while taking Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Interactions for Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Typical Dosage for Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Schedule of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Storage Requirements for Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Effects of Missed Dosage of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Effects of Overdose of Fluocinolone acetonide + Salicylic acid + Benzoic acid

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Fluocinolone acetonide

About Fluocinolone acetonide

A synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation.

Mechanism of Action of Fluocinolone acetonide

Fluocinolone is a topical high potency glucocorticoid.
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.

Pharmacokinets of Fluocinolone acetonide

Absorption: Fluocinolone is absorbed( <1 %) through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier.

Onset of Action for Fluocinolone acetonide

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Duration of Action for Fluocinolone acetonide

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Half Life of Fluocinolone acetonide

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Side Effects of Fluocinolone acetonide

1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8. Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Stinging
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne

Contra-indications of Fluocinolone acetonide

1. Hypersensitivity to Fluocinolone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers

Special Precautions while taking Fluocinolone acetonide

1.Avoid application on large surface area
2. Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
NEONATES: contraindicated

Indications for Fluocinolone acetonide

1.Psoriasis
2.Eczema
3.Otitis externa
4.Lichen simplex and planus
5.Anal and vulval pruritis
6.Contact dermatitis
7.Seborrheic dermatitis
8. Dermatoses (secondary infected)

Interactions for Fluocinolone acetonide

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Typical Dosage for Fluocinolone acetonide

Topical: Fluocinolone 0.0025 %, 0.01% cream, ointment, gel or lotion is used. Clean and dry the affected area and apply the medicament thinly and evenly on the affected area for 2 - 3 times daily for 2 weeks.

Schedule of Fluocinolone acetonide

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Storage Requirements for Fluocinolone acetonide

Store at room temperature. Protect from heat and moisture. Keep out of the reach of children

Effects of Missed Dosage of Fluocinolone acetonide

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Fluocinolone acetonide

Give supportive measures and symptomatic treatment.

Salicylic Acid

About Salicylic Acid

A beta hydroxy acid, Keratolytic, Topical Skin Product(Anti Acne).

Mechanism of Action of Salicylic Acid

It is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle. For milder acne, salicylic acid helps unclog pores to resolve and prevent lesions.

Pharmacokinets of Salicylic Acid

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Onset of Action for Salicylic Acid

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Duration of Action for Salicylic Acid

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Half Life of Salicylic Acid

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Side Effects of Salicylic Acid

1.Allergic reaction
2.Hives
3.Difficulty breathing
4.Swelling of your face, lips, tongue, or throat.

Contra-indications of Salicylic Acid

1.Hypersensitivity to Salicylic acid

Special Precautions while taking Salicylic Acid

1.Avoid contact with eyes, mouth, or nose.
2.Like many other topical acne treatments, salicylic acid must be used continuously, even after acne lesions have.

Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Salicylic Acid

1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.

Interactions for Salicylic Acid

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Typical Dosage for Salicylic Acid

Use this medication twice daily

Schedule of Salicylic Acid

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Storage Requirements for Salicylic Acid

Store in a cool dry place. Protect from heat and light. Keep out of the reach of children

Effects of Missed Dosage of Salicylic Acid

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Salicylic Acid

Give supportive measures and symptomatic treatment.

Benzoic Acid

About Benzoic Acid

Antibacterial. A fungistatic compound,preservatives.

Mechanism of Action of Benzoic Acid

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Pharmacokinets of Benzoic Acid

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Onset of Action for Benzoic Acid

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Duration of Action for Benzoic Acid

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Half Life of Benzoic Acid

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Side Effects of Benzoic Acid

1.Allergic reaction
2.Hives
3.Difficulty breathing
4.Swelling of your face, lips, tongue, or throat.

Contra-indications of Benzoic Acid

1.Hypersensitivity to Benzoic acid

Special Precautions while taking Benzoic Acid

Avoid contact with eyes, mouth, or nose.

Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Benzoic Acid

1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.

Interactions for Benzoic Acid

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Typical Dosage for Benzoic Acid

Use this medication twice daily

Schedule of Benzoic Acid

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Storage Requirements for Benzoic Acid

Store in a cool dry place. Protect from heat and light. Keep out of the reach of children

Effects of Missed Dosage of Benzoic Acid

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Benzoic Acid

Give supportive measures and symptomatic treatment.

Home Delivery for Fluocinolone acetonide + Salicylic acid + Benzoic acid in Your City

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Fluocinolone acetonide + Salicylic acid + Benzoic acid is a generic medicine name and there are several brands available for it. Some of the brands for fluocinolone acetonide + salicylic acid + benzoic acid might be better known than fluocinolone acetonide + salicylic acid + benzoic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluocinolone acetonide + salicylic acid + benzoic acid in stock, you can ask for one of the branded alternatives for fluocinolone acetonide + salicylic acid + benzoic acid.