Piroxicam Pharmacology
Piroxicam
Distribution- Widely distributed in the body as plasma protein bound form (99% bound to the plasma proteins). The drug is distributed into breast milk.
Metabolism- Metabolized in the liver by hydroxylation and glucoronide conjugation to its metabolites.
Excretion- Excreted through urine and bile.
Antirheumatic action: 7- 12 days after administration
2. Heart burn
3. Vomiting
4. Epigastric distress
5. Tinnitus
6. Skin rash
7. Oedema
8. Aplastic anemia
9. Thrombocytopenia
10. Peptic ulceration
11. Photosensitivity
12. Liver enzyme elevation
13. Vertigo
14. Dizziness
2. Active peptic ulcer
3. NSAID induced allergy
4. History of recurrent ulcer
5. Bronchial asthma
2. Renal dysfunction
3. Hypertension
4. Recent surgery
5. Hemorrhagic disorders
2. Osteoarthritis
3. Ankylosing spondylitis
4. Acute musculo-skeletal disorders
5. Acute gout
6. Post-operative & post-traumatic pain
7. Primary dysmenorrhea
Beta-Blockers: Antihypertensive effect may be impaired.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Lithium: Serum lithium levels may be increased.
Hydantoins: Serum hydantoin levels increased resulting in increased pharmacologic and toxic effects.
Methotrexate: Risk of methotrexate toxicity (stomatitis, bone marrow suppression, nephrotoxicity) increased.
Probenecid: May increase the concentration and toxicity of piroxicam.
Aspirin: Displaces piroxicam from serum binding sites resulting in increased incidence of G.I. effects.
Adults-
General dose - 20mg daily as a single dose
Musculo-skeletal disorders- Initially 40mg daily for 2 days then 20mg daily for 7-14 days.
Gout- Initially 40mg as a single then 40mg daily in single or divided doses for next 4-6 days.
Post-operative & post-traumatic pain- 40mg daily in single or divided doses for first two days, then 20mg once daily.
Primary dysmenorrhea- 40mg once daily for first two days, then 20mg once daily for 2-3 days.
Injection-
Same as oral dose by deep I.M. injection into upper outer quadrant of buttocks. For maintenance use oral preparations
For Topical application:
Adults-
Apply 1g gel to affected site 3-4 times daily. Review therapy after 4 weeks.
Home Delivery for Piroxicam in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including piroxicam.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for piroxicam and other medicines and health products. Home delivery services for piroxicam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take piroxicam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for piroxicam before they complete the sale. You can get this information while placing the order for piroxicam with the pharmacy.
Piroxicam is a generic medicine name and there are several brands available for it. Some of the brands for piroxicam might be better known than piroxicam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have piroxicam in stock, you can ask for one of the branded alternatives for piroxicam.