Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate Pharmacology

Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate

About Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Mechanism of Action of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Pharmacokinets of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Onset of Action for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Duration of Action for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Half Life of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Side Effects of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Contra-indications of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Special Precautions while taking Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Interactions for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Typical Dosage for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Schedule of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Storage Requirements for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Effects of Missed Dosage of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A
Effects of Overdose of Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate
N/A

Tolnaftate

About Tolnaftate
Thiocarbamate derivative, Antifungal.
Mechanism of Action of Tolnaftate
Tolnaftate is a reversible noncompetitive inhibitor of Squalene epoxidase enzyme of fungi. This epoxidase enzyme is useful for the conversion of Squalene to sterols. Inhibition of Squalene epoxidase enzyme will leads to a deficiency of sterols (ergosterol) and distort the hyphae and to stunt mycelial growth in susceptible organisms.
Pharmacokinets of Tolnaftate
Absorption: The absorption after topical application is negligible.
Onset of Action for Tolnaftate
N/A
Duration of Action for Tolnaftate
N/A
Half Life of Tolnaftate
N/A
Side Effects of Tolnaftate
1. Irritation
2. Redness
3. Stinging
4. Sensitisation
5. Contact dermatitis
6. Pruritis
Contra-indications of Tolnaftate
1. Hypersensitivity to Tolnaftate
2. Nail and scalp infections
3. Deep infections
Special Precautions while taking Tolnaftate
1. Avoid contact with eyes mouth vagina and nose.
2. Stop the use of medication if irritation occurs
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 2 years: contraindicated
Indications for Tolnaftate
1. Dermatophytosis
2. Tinea corporis (ringworm of the body)
3. Tinea cruris (ringworm of the groin; jock itch)
4. Tinea pedis (ringworm of the foot; athlete`s foot)
5. Tinea versicolor
6. Tinea barbae
Interactions for Tolnaftate
None reported.
Typical Dosage for Tolnaftate
1% cream, gel, powder and topical solution are used.
Clean and dry the affected and surrounding area. Apply the medicament with gentle massage and cover it with surgical gauze 2 - 3 times daily for 2 - 6 weeks. Wash hands before and after use.
Aerosol Powder: Spray liberally from a distance of 15 to 25 cm between toes and on feet, in shoes, socks or on affected area.
Solution: 1 - 2 drops for cover the area of hand; 2 - 3 drops cover the toes. Apply to each lesion and massage gently, then allow drying.
Schedule of Tolnaftate
N/A
Storage Requirements for Tolnaftate
Store at 15 - 25 degree C. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Tolnaftate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolnaftate
Give supportive measures and symptomatic treatment.

Gentamicin

About Gentamicin
Aminoglycoside antibiotic.
Mechanism of Action of Gentamicin
Gentamicin exerts its bactericidal action against gram negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to Gentamicin.
Pharmacokinets of Gentamicin
Absorption: Poorly absorbed orally
Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor.
Metabolism: Not metabolized
Excretion: Excreted mainly through urine.

Onset of Action for Gentamicin
1 hour
Duration of Action for Gentamicin
8 hours
Half Life of Gentamicin
2 hours
Side Effects of Gentamicin
1. Vestibular damage & Ototoxicity
2. Allergic manifestations
3. Nephrotoxicity
4. Dizziness
5. Nausea
6. Vomiting
7. Seizures
Contra-indications of Gentamicin
1. Hypersensitive to the drug or other amino glycosides
2. Along with chloramphenicol or tetracycline
3. Renal impairment
4. Labyrinthine disorders

Special Precautions while taking Gentamicin
1. Renal impairment
2. Neuromuscular disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Infants : Use with caution
Indications for Gentamicin
1. Infections caused by staphylococci, pseudomonas, proteous, klebsiella, enterobacter & serratia.
2. Meningitis.
3. Endocarditis
4. Urinary Tract Infections.
5. Otitis & Ocular infections.
6. Infections of burns & Skin ulcers
Interactions for Gentamicin
Amphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide: Increased nephrotoxicity.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Tests: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.
Typical Dosage for Gentamicin
Dosage:
Adults: 2 to 5mg/kg/day; Thrice daily for a week or more
Children: 2 to 2.5mg/kg; Thrice daily.
Schedule of Gentamicin
H
Storage Requirements for Gentamicin
Store below 30 degree Celsius and protect from light.
Effects of Missed Dosage of Gentamicin
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.
Effects of Overdose of Gentamicin
An overdose results in ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations.Treatment includes removal of drug by dialysis or by treatment with anticholinesterase like neostigmine and by administration of Ca , Prednisolone etc.

Iodochlorohydroxyquinoline

About Iodochlorohydroxyquinoline
A hydroxyquinoline derivative, Antiprotozoal, amebicide.
Mechanism of Action of Iodochlorohydroxyquinoline
N/A
Pharmacokinets of Iodochlorohydroxyquinoline
N/A
Onset of Action for Iodochlorohydroxyquinoline
N/A
Duration of Action for Iodochlorohydroxyquinoline
N/A
Half Life of Iodochlorohydroxyquinoline
N/A
Side Effects of Iodochlorohydroxyquinoline
N/A
Contra-indications of Iodochlorohydroxyquinoline
N/A
Special Precautions while taking Iodochlorohydroxyquinoline
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Iodochlorohydroxyquinoline
N/A
Interactions for Iodochlorohydroxyquinoline
N/A
Typical Dosage for Iodochlorohydroxyquinoline
N/A
Schedule of Iodochlorohydroxyquinoline
N/A
Storage Requirements for Iodochlorohydroxyquinoline
N/A
Effects of Missed Dosage of Iodochlorohydroxyquinoline
N/A
Effects of Overdose of Iodochlorohydroxyquinoline
N/A

Chlorocresol

About Chlorocresol
A potent chlorinated phenolic compound, Bactericide ,Antiseptic , Disinfectant, Preservative.

Mechanism of Action of Chlorocresol
Chlorocresol is a potent chlorinated phenolic disinfectant, antiseptic and bactericide. It has bactericidal activity against Gram-positive and Gram-negative bacteria and is effective against fungi but has little activity against bacterial spores except at high temperatures. It is more active in acid than in alkaline solution.
Chlorocresol is used in preparations for disinfection of the skin and wounds. It is also used as a preservative in cosmetics and in creams and other preparations for external use that contain water.
Chlorocresol is used as a preservative in aqueous injections issued in multidose containers. It is used as a preservative in pharmaceutical creams and lotions, especially steroid creams.
Chlorocresol is used in preparations for disinfection of the skin and wounds. It is also used as a preservative in cosmetics and in creams and other preparations for external use that contain water.
Pharmacokinets of Chlorocresol
Absorption: It is applied topically
Onset of Action for Chlorocresol
N/A
Duration of Action for Chlorocresol
N/A
Half Life of Chlorocresol
N/A
Side Effects of Chlorocresol
Sensitisation reactions
Contra-indications of Chlorocresol
Hypersensitivity to the drug
Special Precautions while taking Chlorocresol
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Chlorocresol
Antiseptic
Interactions for Chlorocresol
N/A
Typical Dosage for Chlorocresol
As directed by the Physician
Schedule of Chlorocresol
N/A
Storage Requirements for Chlorocresol
Store at room temperature away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Chlorocresol
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Chlorocresol
Give supportive measures and symptomatic treatment.

Betamethasone valerate

About Betamethasone valerate
It is a topical steroid
Mechanism of Action of Betamethasone valerate
The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone valerate
Absorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.

Onset of Action for Betamethasone valerate
N/A
Duration of Action for Betamethasone valerate
N/A
Half Life of Betamethasone valerate
N/A
Side Effects of Betamethasone valerate
1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone valerate
1.Untreated bacterial, virus or fungal infections
2.Acne vulgaris,
3.Peri-oral dermatitis,
4.Scabies,
5.Leg ulcers,
6.Tuberculosis of the skin,
7.Varicose ulcers,
8.Skin lesions caused by infections with ring worm,. fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo)
9.Hypersensitivity to Betamethasone and other corticosteroids.
10.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone valerate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Betamethasone valerate
1.Psoriasis,
2.Eczema,
3.Otitis externa,
4.Lichen simplex and planus,
5.Anal and vulval Pruritis,
6.Seborrheic dermatitis,
7.Contact dermatitis,
8.Steroidal responsive dermatoses of the scalp
Interactions for Betamethasone valerate
N/A
Typical Dosage for Betamethasone valerate
Topical:
Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption.
Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks.
Schedule of Betamethasone valerate
N/A
Storage Requirements for Betamethasone valerate
Store at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Betamethasone valerate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Betamethasone valerate
Provide symptomatic treatment and supportive measures.

Home Delivery for Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate and other medicines and health products. Home delivery services for tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate before they complete the sale. You can get this information while placing the order for tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate with the pharmacy.

Tolnaftate + Gentamicin + Iodochlorohydroxyquinoline + Chlorocresol + Betamethasone valerate is a generic medicine name and there are several brands available for it. Some of the brands for tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate might be better known than tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate in stock, you can ask for one of the branded alternatives for tolnaftate + gentamicin + iodochlorohydroxyquinoline + chlorocresol + betamethasone valerate.