Prednisolone (Eye Pre.) Pharmacology

Prednisolone (Eye Pre.)

About Prednisolone (Eye Pre.)
Ophthalmic synthetic Glucocorticoid, Ophthalmic anti-inflammatory.
Mechanism of Action of Prednisolone (Eye Pre.)
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action with little mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction. Prednisolone acetate 1% ophthalmic solution is used for inflammation of eye. Prednisolone acetate is 3 to 5 times more active than Hydrocortisone.

Pharmacokinets of Prednisolone (Eye Pre.)
Absorption: It is absorbed after instilled into the eye.
Onset of Action for Prednisolone (Eye Pre.)
N/A
Duration of Action for Prednisolone (Eye Pre.)
N/A
Half Life of Prednisolone (Eye Pre.)
N/A
Side Effects of Prednisolone (Eye Pre.)
1.Transient burning
2.Stinging
3.Ocular irritation
4.Blurred vision
5.Allergic reactions
Contra-indications of Prednisolone (Eye Pre.)
1.Hypersensitivity to Prednisolone eye preparations
2.Epithelial herpes simplex keratitis
3.Bacterial and fungal infection of the eye
Special Precautions while taking Prednisolone (Eye Pre.)
1.Prolonged use
2.Cataract
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
Indications for Prednisolone (Eye Pre.)
Inflammation of eye
Interactions for Prednisolone (Eye Pre.)
N/A
Typical Dosage for Prednisolone (Eye Pre.)
Instil 1-2 drops into the affected eye 2-4 times daily.
Schedule of Prednisolone (Eye Pre.)
N/A
Storage Requirements for Prednisolone (Eye Pre.)
Store in a cool place. Protect from light. Keep out of the reach of children.
Effects of Missed Dosage of Prednisolone (Eye Pre.)
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Prednisolone (Eye Pre.)
Give supportive measures and symptomatic treatment.

Home Delivery for Prednisolone (Eye Pre.) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including prednisolone (eye pre.).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for prednisolone (eye pre.) and other medicines and health products. Home delivery services for prednisolone (eye pre.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take prednisolone (eye pre.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for prednisolone (eye pre.) before they complete the sale. You can get this information while placing the order for prednisolone (eye pre.) with the pharmacy.

Prednisolone (Eye Pre.) is a generic medicine name and there are several brands available for it. Some of the brands for prednisolone (eye pre.) might be better known than prednisolone (eye pre.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have prednisolone (eye pre.) in stock, you can ask for one of the branded alternatives for prednisolone (eye pre.).