Dexamethasone (Eye Pre.) Pharmacology

Dexamethasone (Eye Pre.)

About Dexamethasone (Eye Pre.)
N/A
Mechanism of Action of Dexamethasone (Eye Pre.)
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)
Absorption: Dexamethasone is minimally absorbed after instillation into the eye
Onset of Action for Dexamethasone (Eye Pre.)
N/A
Duration of Action for Dexamethasone (Eye Pre.)
N/A
Half Life of Dexamethasone (Eye Pre.)
N/A
Side Effects of Dexamethasone (Eye Pre.)
1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)
1.Hypersensitivity to Dexamethasone
Special Precautions while taking Dexamethasone (Eye Pre.)
1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma



Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Dexamethasone (Eye Pre.)
1.Ophthalmic disorders
2.Eye inflammation
Interactions for Dexamethasone (Eye Pre.)
N/A
Typical Dosage for Dexamethasone (Eye Pre.)
Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)
N/A
Storage Requirements for Dexamethasone (Eye Pre.)
Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Dexamethasone (Eye Pre.)
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dexamethasone (Eye Pre.)
Give supportive measures and symptomatic treatment.

Home Delivery for Dexamethasone (Eye Pre.) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dexamethasone (eye pre.).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dexamethasone (eye pre.) and other medicines and health products. Home delivery services for dexamethasone (eye pre.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dexamethasone (eye pre.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexamethasone (eye pre.) before they complete the sale. You can get this information while placing the order for dexamethasone (eye pre.) with the pharmacy.

Dexamethasone (Eye Pre.) is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) might be better known than dexamethasone (eye pre.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.).