Miglitol Pharmacology

Miglitol

About Miglitol
Alpha-glucosidase inhibitor,Piperidine derivative, Oral anti-diabetic drug.
Mechanism of Action of Miglitol
The drug exerts it`s antihyperglycaemic action by causing reversible competitive inhibition of membrane bound intestinal alpha-glucosidase hydrolase enzymes; which are the final enzymes in the carbohydrate digestion in the brush border of small intestinal mucosa. It also inhibits sucrase and weak inhibitory effects on pancreatic a-amylase and reduces digestion and absorption of polysaccharides and sucrose, lowers HbA1c, body weight and serum triglyceride levels. It delays and reduces glucose absorption and lowers postprandial hyperglycaemia.
Pharmacokinets of Miglitol
Absorption: Absorption of drug is saturable at higher doses; a dose of 25mg is completely absorbed but at high dose of 100mg, only about 50 to 70% is absorbed, Distribution: It acts locally within the gastrointestinal tract; and distributed extracellularly, Metabolism: It is not metabolized in the body, Excretion: Excreted mainly through urine as unchanged drug.
Onset of Action for Miglitol
N/A
Duration of Action for Miglitol
N/A
Half Life of Miglitol
2 hours
Side Effects of Miglitol
1.Flatulence
2.Loose stools
3.Abdominal pain
4.Diarrhoea
5.Decreased serum iron
6.Rashes
Contra-indications of Miglitol
1.Hypersensitivity to the drug
2.Diabetic ketoacidosis
3.Ulcerative colitis
4.Partial intestinal obstruction
5.Chronic intestinal diseases
6.Severe renal impairment
Special Precautions while taking Miglitol
1.Mild to moderate renal impairment
2.Along with insulin or sulfonylureas
3.Enhance hypoglycaemic effects of sulfonylureas give glucose in such situations
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Miglitol
As monotherapy as an adjunct to diet to improve glycemic control in patients with type 2 diabetes. Can be used in combination with sulphonylurea, metformin and/or insulin.
Interactions for Miglitol
No serious drug interaction reported.
Typical Dosage for Miglitol
Oral: 25mg thrice daily; start with the 1st bite of each main meal. Increased to 50mg thrice daily after 4 to 8 week. Then increased to 100mg thrice daily after 3 months if required based on the glycosylated haemoglobin level.
Schedule of Miglitol
N/A
Storage Requirements for Miglitol
Store at controlled room temperature at a range of 15 to 30 degree C. in a well closed container. Protect from moisture. Keep out of reach of children.
Effects of Missed Dosage of Miglitol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Miglitol
Provide symptomatic treatment and supportive measures.

Home Delivery for Miglitol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including miglitol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for miglitol and other medicines and health products. Home delivery services for miglitol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take miglitol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for miglitol before they complete the sale. You can get this information while placing the order for miglitol with the pharmacy.

Miglitol is a generic medicine name and there are several brands available for it. Some of the brands for miglitol might be better known than miglitol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have miglitol in stock, you can ask for one of the branded alternatives for miglitol.