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- Pharmacology For Cisapride + Dimethicone
Cisapride + Dimethicone Pharmacology
Cisapride + Dimethicone
About Cisapride + DimethiconeN/AMechanism of Action of Cisapride + DimethiconeN/APharmacokinets of Cisapride + DimethiconeN/AOnset of Action for Cisapride + DimethiconeN/ADuration of Action for Cisapride + DimethiconeN/AHalf Life of Cisapride + DimethiconeN/ASide Effects of Cisapride + DimethiconeN/AContra-indications of Cisapride + DimethiconeN/ASpecial Precautions while taking Cisapride + DimethiconeN/APregnancy Related InformationContraindicated; since Cisapride is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Cisapride + Dimethicone1.Functional dyspepsia
2.Gastro esophageal reflux diseases
Interactions for Cisapride + DimethiconeN/ATypical Dosage for Cisapride + DimethiconeAdult: 1 tablet to be taken 15minutes before each meal and at bed time.Schedule of Cisapride + DimethiconeN/AStorage Requirements for Cisapride + DimethiconeN/AEffects of Missed Dosage of Cisapride + DimethiconeN/AEffects of Overdose of Cisapride + DimethiconeN/ACisapride
About CisaprideA serotonin 5-HT4 receptor agonist, parasympathomimetic, Gastrointestinal prokinetic agent.Mechanism of Action of CisaprideCisapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Cisapride produces 5HT3 antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of CisaprideAbsorption: Cisapride is well absorbed after oral administration.
Distribution: It is very rapidly distributed in the body mainly to tissues in protein bound forms.
Metabolism: Cisapride is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and faeces.
Onset of Action for Cisapride30 - 60 minutesDuration of Action for Cisapride7 - 10 hoursHalf Life of Cisapride6 - 12 hoursSide Effects of Cisapride1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Constipation
5.Nausea
6.Urinary frequency
7.Rhinitis
8.Cough
Contra-indications of Cisapride1.Hypersensitivity to Cisapride
2.Ventricular tachycardia
3.Ventricular fibrillation
4.Ventricular arrhythmia
5.Torsades de pointes
6.Ischaemic heart diseases
7.Congestive heart failure
8.Hypokalaemia
9.Respiratory failure
10.Hypokalaemia
11.Hypomagnesaemia
12.Respiratory failure
13.Renal failure
14.Gastrointestinal haemorrhag
Special Precautions while taking Cisapride1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: use with cautionIndications for Cisapride1.Gastroesophageal reflux diseases
2.Gastroparesis
3.Non ulcer dyspepsia
4.Disorders associated with decreased gastric motility
5.Chronic constipation
6.Nausea
Interactions for CisaprideDiazepam: Enhanced efficacy by cisapride due to increased gastric emptying.
Alcohol: Sedative effect augmented.
Anti-convulsants: Plasma levels of anticonvulsants must be carefully montiored.
Anti-coagulants: Prothrombin time increased.
Anti-cholinergics: Antagonize the effects of cisapride.
Typical Dosage for CisaprideAdult:
Oral: 40 mg / day in 4 divided doses 15 minutes before each meal and at bed time. Dose can be increased if needed to 80 mg / day.
Non ulcer dyspepsia: 30 mg / day in 3 divided doses for 1 month.
Gastroesophageal reflux diseases: 30 mg / day in 3 divided doses for 3 months and if needed additional 10 mg can be given at bed time.
Disorders associated with decreased gastric motility: 30 - 40 mg / day in 3 - 4 divided doses for 1 ? months.
Chronic constipation: 15 mg / day in 3 divided doses; dose can be increased to 30 mg / day if necessary.
Children (suspension only): 0.2 mg 3 times daily, maximum daily dose is 0.8 mg / kg / day.
Schedule of CisaprideN/AStorage Requirements for CisaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of CisaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CisaprideGive supportive measures and symptomatic treatment.
Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal.
Dimethicone
About DimethiconeOral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.Mechanism of Action of DimethiconeActivated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of DimethiconeN/AOnset of Action for DimethiconeN/ADuration of Action for DimethiconeN/AHalf Life of DimethiconeN/ASide Effects of DimethiconeN/AContra-indications of DimethiconeHypersensitivity to Dimethicone activatedSpecial Precautions while taking DimethiconeKidney failurePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dimethicone1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for DimethiconeN/ATypical Dosage for Dimethicone125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of DimethiconeN/AStorage Requirements for DimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of DimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DimethiconeGive symptomatic and supportive treatment.Home Delivery for Cisapride + Dimethicone in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cisapride + dimethicone and other medicines and health products. Home delivery services for cisapride + dimethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Cisapride + Dimethicone is a generic medicine name and there are several brands available for it. Some of the brands for cisapride + dimethicone might be better known than cisapride + dimethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cisapride + dimethicone in stock, you can ask for one of the branded alternatives for cisapride + dimethicone.