Cisapride Pharmacology

Cisapride

About Cisapride
A serotonin 5-HT4 receptor agonist, parasympathomimetic, Gastrointestinal prokinetic agent.
Mechanism of Action of Cisapride
Cisapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Cisapride produces 5HT3 antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.
Pharmacokinets of Cisapride
Absorption: Cisapride is well absorbed after oral administration.
Distribution: It is very rapidly distributed in the body mainly to tissues in protein bound forms.
Metabolism: Cisapride is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and faeces.
Onset of Action for Cisapride
30 - 60 minutes
Duration of Action for Cisapride
7 - 10 hours
Half Life of Cisapride
6 - 12 hours
Side Effects of Cisapride
1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Constipation
5.Nausea
6.Urinary frequency
7.Rhinitis
8.Cough
Contra-indications of Cisapride
1.Hypersensitivity to Cisapride
2.Ventricular tachycardia
3.Ventricular fibrillation
4.Ventricular arrhythmia
5.Torsades de pointes
6.Ischaemic heart diseases
7.Congestive heart failure
8.Hypokalaemia
9.Respiratory failure
10.Hypokalaemia
11.Hypomagnesaemia
12.Respiratory failure
13.Renal failure
14.Gastrointestinal haemorrhag

Special Precautions while taking Cisapride
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: use with caution
Indications for Cisapride
1.Gastroesophageal reflux diseases
2.Gastroparesis
3.Non ulcer dyspepsia
4.Disorders associated with decreased gastric motility
5.Chronic constipation
6.Nausea
Interactions for Cisapride
Diazepam: Enhanced efficacy by cisapride due to increased gastric emptying.
Alcohol: Sedative effect augmented.
Anti-convulsants: Plasma levels of anticonvulsants must be carefully montiored.
Anti-coagulants: Prothrombin time increased.
Anti-cholinergics: Antagonize the effects of cisapride.
Typical Dosage for Cisapride
Adult:
Oral: 40 mg / day in 4 divided doses 15 minutes before each meal and at bed time. Dose can be increased if needed to 80 mg / day.
Non ulcer dyspepsia: 30 mg / day in 3 divided doses for 1 month.
Gastroesophageal reflux diseases: 30 mg / day in 3 divided doses for 3 months and if needed additional 10 mg can be given at bed time.
Disorders associated with decreased gastric motility: 30 - 40 mg / day in 3 - 4 divided doses for 1 ? months.
Chronic constipation: 15 mg / day in 3 divided doses; dose can be increased to 30 mg / day if necessary.
Children (suspension only): 0.2 mg 3 times daily, maximum daily dose is 0.8 mg / kg / day.
Schedule of Cisapride
N/A
Storage Requirements for Cisapride
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Cisapride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cisapride
Give supportive measures and symptomatic treatment.
Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Cisapride in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cisapride.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cisapride and other medicines and health products. Home delivery services for cisapride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cisapride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cisapride before they complete the sale. You can get this information while placing the order for cisapride with the pharmacy.

Cisapride is a generic medicine name and there are several brands available for it. Some of the brands for cisapride might be better known than cisapride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cisapride in stock, you can ask for one of the branded alternatives for cisapride.