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- Pharmacology For Paracetamol + Racemethionine
Paracetamol + Racemethionine Pharmacology
Paracetamol + Racemethionine
About Paracetamol + RacemethionineN/AMechanism of Action of Paracetamol + RacemethionineN/APharmacokinets of Paracetamol + RacemethionineN/AOnset of Action for Paracetamol + RacemethionineN/ADuration of Action for Paracetamol + RacemethionineN/AHalf Life of Paracetamol + RacemethionineN/ASide Effects of Paracetamol + RacemethionineN/AContra-indications of Paracetamol + RacemethionineN/ASpecial Precautions while taking Paracetamol + RacemethionineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Paracetamol + RacemethionineN/AInteractions for Paracetamol + RacemethionineN/ATypical Dosage for Paracetamol + RacemethionineN/ASchedule of Paracetamol + RacemethionineN/AStorage Requirements for Paracetamol + RacemethionineN/AEffects of Missed Dosage of Paracetamol + RacemethionineN/AEffects of Overdose of Paracetamol + RacemethionineN/AParacetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Racemethionine
About RacemethionineA sulfur containing essential amino acid , Urinary Acidifier, paracetamol antidote.Mechanism of Action of RacemethionineRacemethionine is a urine acidifier. Racemethionine produces ammonia-free urine by lowering the urinary pH. Along with Paracetamol, Racemethionine provides a liver friendly analgesic and antipyretic Acidifier.
Racemethionine enhances the synthesis of glutathione and is used as an alternative to Acetylcysteine in the treatment of paracetamol poisoning to prevent hepatotoxicity.
It maintain hepatic concentrations of glutathione which is required to inactivate an hepatotoxic intermediate metabolite of acetaminophen.In acetaminophen overdose, excessive quantities of this metabolite are formed because the primary metabolic pathways (glucuronide and sulfate conjugation) become saturated. The excess metabolite binds irreversibly to essential hepatic proteins and enzymes, causing cell damage and death. Racemethionine serves as a precursor for the synthesis of glutathione and sulfate.
Pharmacokinets of RacemethionineN/AOnset of Action for RacemethionineN/ADuration of Action for RacemethionineN/AHalf Life of RacemethionineN/ASide Effects of Racemethionine1.Drowsiness
2.Nausea
3.Vomiting
Contra-indications of Racemethionine1.Acidosis
2.Severe liver disease
Special Precautions while taking Racemethionine1.Acidosis
2.Hepatic impairment
3.Allergies
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Racemethionine1. Urinary acidifier
2. Paracetamol poisoning
Interactions for RacemethionineN/ATypical Dosage for RacemethionineAs directed by the physician
As urinary acidifier:
Adults : 200 mg 3 or 4 times a day.
Children: Same as adult dose
Schedule of RacemethionineN/AStorage Requirements for RacemethionineStore away from heat and direct light. Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.
Effects of Missed Dosage of RacemethionineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Do not double the dose. Continue the regular scheduleEffects of Overdose of RacemethionineGive supportive measures and symptomatic treatment.Home Delivery for Paracetamol + Racemethionine in Your City
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