Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron Pharmacology

Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

About Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Mechanism of Action of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Pharmacokinets of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Onset of Action for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Duration of Action for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Half Life of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Side Effects of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Contra-indications of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Special Precautions while taking Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Pregnancy Related Information

Use with caution

Old Age Related Information

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Breast Feeding Related Information

Use with caution

Children Related Information

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Indications for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

1.Calcium deficiency
2.Osteoporosis in males
3.Post-menopausal osteoporosis.
4.Rickets
5.Osteocalcaemia
6.Mineral supplement

Interactions for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Typical Dosage for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

Adult: 1 capsule / day and if needed dose can be increased by 1 capsule every 2 week

Schedule of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Storage Requirements for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Effects of Missed Dosage of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Effects of Overdose of Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron

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Calcium

About Calcium

Calcium is necessary for cardiac function, muscle contraction, nervous activity, coagulation of blood and for maintaining structural integrity of cell membranes.
Plasma concentration of calcium is kept in normal range by three endocrine factors which control metabolism of calcium. These are (a) Parathyroid hormone, (b) Calcitonin, (c) Vitamin D. Calcium in plasma is bound to albumin, is complexed with anions (e.g. phosphate) and as diffusible ionic calcium. The physiological effects are exerted by ionic calcium. The predominant source of calcium is dairy products and the daily intake varies from 200 - 2500 mg. Adequate calcium intake is particularly important during periods of bone growth in childhood and adolescence and during pregnancy and lactation.
Patients with advanced renal insufficiency exhibit phosphate retention and some degree of hyperphosphataemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy and soft tissue calcification. Calcium acetate, when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the faeces.
Deficiency signs and symptoms: Osteoporosis, pathological fractures, brittle nails and hair.

Mechanism of Action of Calcium

Calcium is essential for maintaining the functional integrity of nervous, muscular, and skeletal system. It controls excitability of nerves and muscles and regulates permeability of cell membrane. It also regulates cell adhesion and maintains integrity of cell membrane. Calcium acts as intracellular messenger for hormones, autacoids, and transmitters. It is required for excitation-contraction coupling in all types of muscle and excitation-secretion coupling in exocrine and endocrine glands. It is essential for release of transmitters from nerve endings and other release reactions. It is also essential for impulse generation in heart and determines level of automaticity and
A-V conduction. Calcium is also required for blood-coagulation.

Pharmacokinets of Calcium

Absorption: Actively absorbed from gastrointestinal tract in an ionized form; and vitamin D in it`s active form is required for calcium absorption, Distribution: Distributed mainly in to skeletal tissue (99%) and 1% is distributed equally between the intracellular and extra cellular fluid. CSF levels are about half of the serum calcium levels, Metabolism: Not significantly metabolized in the body, Excretion: Excreted mainly through faeces and a small amount is excreted through urine.

Onset of Action for Calcium

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Duration of Action for Calcium

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Half Life of Calcium

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Side Effects of Calcium

1.Constipation
2.Bloating
3.Excess gas
4.Anorexia
5.Nausea
6.Vomiting
7.Abdominal pain
8.Thirst
9.Hypercalcaemia
10.Polyuria
11.Dry mouth
12.Delirium
13.Confusion

Contra-indications of Calcium

1.Renal calculi
2.Hypophosphataemia
3.Hypercalcaemia
4.Ventricular fibrillation.

Special Precautions while taking Calcium

1.Renal impairment
2.Cardiac diseases
3.Sarcoidosis
4.Cor pulmonale
5.Respiratory acidosis
6.Respiratory failure
7.End stage renal failure
8.Hypoparathyroid patients
9.Digitalized patients
10.Prolonged use of therapeutic amounts.

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

May be used

Children Related Information

Use with caution

Indications for Calcium

1.Hypocalcaemia
2.Calcium and vitamin D deficiency
3.Calcium deficiency during pregnancy and lactation
4.Rickets
5.Prevention of osteoporosis in postmenopausal women
6.Chronic renal failure.

Interactions for Calcium

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Typical Dosage for Calcium

Oral: 500mg to 2g daily in two to four divided doses.
Hypocalcaemia:
Adults: 1g daily. Increases to 2g daily if required.
Prevention of osteoporosis: 1 to 1.5g daily.
Children: 45 to 65mg/kg daily.
Neonates: 50 to 150mg/kg and should not exceed 1g.

Schedule of Calcium

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Storage Requirements for Calcium

Store in a well closed container in a cool and dry place. Protect from light.

Effects of Missed Dosage of Calcium

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Calcium

Remove calcium from stomach by induced emesis and gastric lavage. Provide symptomatic treatment and supportive measures.

Vitamin D3

About Vitamin D3

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Mechanism of Action of Vitamin D3

Vitamin D3 is a form of vitamin D. It is also called as Cholecalciferol.7-Dehydrocholesterol is the precursor of vitamin D3 and only forms the vitamin after being exposed to UV radiation.After exposure to the sun, cholecalciferol is sent to the liver to be hydroxylated where it becomes 25-Hydroxyvitamin D3.Next, it is sent to the kidney and once again hydroxylated becoming 1,25-Hydroxyvitamin D3. 1,25-Hydroxyvitmain D3 is the active form of vitamin D3, for this reason vitamin D is often referred to as a prohormone.Vitamin D exerts it`s action by influencing calcium homoeostasis. It increases the intestinal absorption of calcium and phosphate. It binds to the cytoplasmic Vitamin D receptor and translocates to the nucleus and thus increases the synthesis of specific m RNA and regulates protein synthesis. It increases the synthesis of a carrier protein for calcium called "calbindin" or calcium binding protein. Activation of Vitamin D receptor enhances endocytotic capture of calcium and it`s transport across duodenal mucosal cells in a vesicular form. Vitamin D promotes resorption of calcium and phosphate from bone by enhancing recruitment and differentiation of osteoclast precursors in the bone remodeling units. It helps in bone mineralization.

Pharmacokinets of Vitamin D3

Absorption: Well absorbed orally in the presence of bile salts, Malabsorption and steatorrhoea interfere with it`s absorption.
Distribution: Widely distributed in a protein bound form. It is stored in adipose tissue and liver.
Metabolism: It is hydroxylated in to both active and inactive metabolites and also metabolized in kidney.
Excretion: Metabolites are excreted mainly through bile.

Onset of Action for Vitamin D3

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Duration of Action for Vitamin D3

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Half Life of Vitamin D3

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Side Effects of Vitamin D3

1. Hypercalcaemia
2. Fatigue
3. Weakness
4. Diarrhoea
5. Vomiting
6. Sluggishness
7. Albuminuria
8. Polyuria
9. Calcification of soft tissues (blood vessels, parenchymal organs including heart)
10. Arrhythmias
11. Renal stones
12. Growh retardation in children
13. Hypertension
14. Anorexia
15. Nausea
16. Constipation
17. Elevated liver enzymes

Contra-indications of Vitamin D3

1. Hypercalcaemia
2. Hypervitaminosis D
3. Renal osteodystrophy with hyperphosphatemia
4. Renal impairment

Special Precautions while taking Vitamin D3

1. Renal diseases
2. Renal stones
3. Cardiac diseases
4. Arteriosclerosis
5. Coronary diseases

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution

Indications for Vitamin D3

1. Rickets and Osteomalacia
2. Hypoparathyroidism
3. Fanconi`s syndrome
4. Osteoporosis

Interactions for Vitamin D3

Antacids: Hypermagnesemia may develop in patients on renal dialysis who take magnesium containing antacids.
Digitalis glycosides: May precipitate cardiac arrhythmias due to hypercalcemia.
Verapamil: Atrial fibrillation may occur.
Cholestyramine: Intestinal absorption of Vitamin D may be reduced.
Mineral Oil: Prolonged use of mineral oil may result in reduced absoprtion of Vitamin D.
Phenytoin, Barbiturates: Half life of vitamin D may be reduced.
Thaizide diuretics: Hypoparathyroid patients on Vitamin D may develop hypercalcemia due to thiazide diuretics.

Typical Dosage for Vitamin D3

Oral:
Adults:
Nutritional Rickets and Osteomalacia: 25 to 125mcg daily in normal gastrointestinal absorption. In severe malabsorption; 250mcg to 7.5mg orally or 250mcg I.M.
Vitamin dependent Rickets: 250mcg to 1.5mg daily
Hypoparathyroidism: 625mcg to 5mg daily with calcium supplements
Fanconi`s syndrome: 1.25 to 5mg daily
Osteoporosis: 25 to 250mcg daily or 1.25mg once weekly with calcium and fluoride supplements.
Hypophosphatemia: 250mcg to 1.5mg along with phosphate supplements
Children:
Nutritional Rickets and Osteomalacia: 25 to 125mcg daily in normal gastrointestinal absorption. In severe malabsorption; 250mcg to 625mcg orally
Vitamin dependent Rickets: 75 to 125mcg daily.
Fanconi`s syndrome: 625mcg to 1.25mg daily
Hypophosphatemia: 1 to 2mg daily with phosphate supplements. Increase the dose in increments of 250 to 500mcg at intervals of 3 to 4months until desired therapeutic response is obtained.

Schedule of Vitamin D3

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Storage Requirements for Vitamin D3

Store in a well closed container in a cool place. Protect from light and excess heat. Keep out of reach of children.

Effects of Missed Dosage of Vitamin D3

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin D3

Provide supportive and symptomatic treatment. Stops the treatment and starting a low calcium diet. Increases the fluid intake and administer Loop diuretics like furosemide may be given with saline I.V. infusion to increase calcium excretion. Calcitonin may decrease hypercalcaemia.

Magnesium

About Magnesium

Magnesium is essential for enzyme activity, calcium and potassium uptake, nerve transmission, bone formation and metabolism of carbohydrates and minerals. It is magnesium, not calcium, which helps form hard tooth enamel, resistant to decay. Like calcium and chloride, magnesium also plays a role in regulating the acid-alkaline balance in the body. High magnesium levels in drinking water have been linked to resistance to heart disease. Although it is found in many foods, including dairy products, nuts, vegetables, fish, meat and seafood, deficiencies are common in America due to soil depletion, poor absorption and lack of minerals in drinking water. A diet high in carbohydrates, oxalic acid in foods like raw spinach and phytic acid found in whole grains can cause deficiencies. An excellent source of usable magnesium is beef, chicken or fish broth. High amounts of zinc and vitamin D increase magnesium requirements. Magnesium deficiency can result in coronary heart disease, chronic weight loss, obesity, fatigue, epilepsy and impaired brain function. Chocolate cravings are a sign of magnesium deficiency.

Mechanism of Action of Magnesium

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Pharmacokinets of Magnesium

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Onset of Action for Magnesium

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Duration of Action for Magnesium

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Half Life of Magnesium

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Side Effects of Magnesium

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Contra-indications of Magnesium

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Special Precautions while taking Magnesium

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Magnesium

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Interactions for Magnesium

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Typical Dosage for Magnesium

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Schedule of Magnesium

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Storage Requirements for Magnesium

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Effects of Missed Dosage of Magnesium

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Effects of Overdose of Magnesium

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Manganese

About Manganese

Mechanism of Action of Manganese

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Pharmacokinets of Manganese

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Onset of Action for Manganese

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Duration of Action for Manganese

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Half Life of Manganese

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Side Effects of Manganese

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Contra-indications of Manganese

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Special Precautions while taking Manganese

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Manganese

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Interactions for Manganese

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Typical Dosage for Manganese

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Schedule of Manganese

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Storage Requirements for Manganese

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Effects of Missed Dosage of Manganese

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Effects of Overdose of Manganese

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Zinc

About Zinc

Trance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.

Mechanism of Action of Zinc

Zinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.

Pharmacokinets of Zinc

Absorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.

Onset of Action for Zinc

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Duration of Action for Zinc

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Half Life of Zinc

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Side Effects of Zinc

1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes

Contra-indications of Zinc

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Special Precautions while taking Zinc

1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction

Pregnancy Related Information

Use with caution

Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Zinc

1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia

Interactions for Zinc

Fluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.

Typical Dosage for Zinc

Adults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.

Schedule of Zinc

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Storage Requirements for Zinc

Store at a temperature below 30 degree C

Effects of Missed Dosage of Zinc

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Zinc

Provide symptomatic treatment and supportive measures

Boron

About Boron

Micronutrient, Dietary mineral.

Mechanism of Action of Boron

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Pharmacokinets of Boron

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Onset of Action for Boron

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Duration of Action for Boron

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Half Life of Boron

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Side Effects of Boron

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Contra-indications of Boron

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Special Precautions while taking Boron

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Boron

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Interactions for Boron

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Typical Dosage for Boron

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Schedule of Boron

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Storage Requirements for Boron

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Effects of Missed Dosage of Boron

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Effects of Overdose of Boron

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Home Delivery for Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including calcium + vitamin d3 + magnesium + manganese + zinc + boron.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for calcium + vitamin d3 + magnesium + manganese + zinc + boron and other medicines and health products. Home delivery services for calcium + vitamin d3 + magnesium + manganese + zinc + boron may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take calcium + vitamin d3 + magnesium + manganese + zinc + boron only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for calcium + vitamin d3 + magnesium + manganese + zinc + boron before they complete the sale. You can get this information while placing the order for calcium + vitamin d3 + magnesium + manganese + zinc + boron with the pharmacy.

Calcium + Vitamin D3 + Magnesium + Manganese + Zinc + Boron is a generic medicine name and there are several brands available for it. Some of the brands for calcium + vitamin d3 + magnesium + manganese + zinc + boron might be better known than calcium + vitamin d3 + magnesium + manganese + zinc + boron itself. If the pharmacy that's willing to deliver medicines to your home doesn't have calcium + vitamin d3 + magnesium + manganese + zinc + boron in stock, you can ask for one of the branded alternatives for calcium + vitamin d3 + magnesium + manganese + zinc + boron.