Zoledronic acid Pharmacology

Zoledronic acid

About Zoledronic acid
Third-generation bisphosphonate, Osteoclastic bone resorption inhibitor(Calcium regulator).
Mechanism of Action of Zoledronic acid
Zoledronate is a third generation bisphosphonate. It is an analogue of pyrophosphate in which the P-O-P bond is replaced by a non hydrolysable P-C-P bond. With divalent cation such as Ca2+ (calcium ion) in the bone, they can capable to form chelating complex and form a three dimensional structure. It has high affinity for active remodeling site in the bone. Bisphosphonate retard formation and dissolution of hydroxy apatite crystals within bone and other site. Bisphosphonate remain in the matrix until the bone is remolded and then released in the acid environment of the resorption lacunae beneath the osteoclasts as the overlying mineral matrix is dissolved. It produces antiresorptive action by osteoclasts apoptosis activity and by inhibition of components of the cholesterol biosynthetic pathway.

Pharmacokinets of Zoledronic acid
Absorption: It is completely absorbed after parenteral administration. Metabolism: It does not undergo metabolism. Excretion: It is excreted mainly in urine.
Onset of Action for Zoledronic acid
N/A
Duration of Action for Zoledronic acid
N/A
Half Life of Zoledronic acid
6 - 7 days
Side Effects of Zoledronic acid
1.Nausea
2.Vomiting
3.Diarrhea
4.Constipation
5.Headache
6.Conjunctivitis
7.Taste disturbances
8.Dry mouth
9.Stomatitis
10.Dyspnoea
11.Upset stomach
12.Anorexia
13.Cough
14.Dizziness
15.Paresthesia
16.Tremor
17.Anxiety
18.Weight loss
19.Heartburn redness
20.Swelling
21.Agitation
22.Sleep disturbances
23.Cough
24.Blurred vision
25.Pruritus
26.Rash
27.Sweating
28.Haematuria
29.Proteinuria
30.Hypophosphataemia
31.Hyperkalaemia
32.Hypokalaemia
33.Hypernatraemia
34.Anaemia
35.Fever
36.Decreased urination
Contra-indications of Zoledronic acid
Hypersensitivity to Zoledronic acid and other bisphosphonates
Special Precautions while taking Zoledronic acid
1.Renal impairment
2.Hepatic impairment
3.Cardiac disease
4.Asthma
5. Hypocalcaemia
6.Hypophosphatemia
7.Hypomagnesemia
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Zoledronic acid
1.Hypercalcaemia of malignancy
2.Multiple myeloma
Interactions for Zoledronic acid
N/A
Typical Dosage for Zoledronic acid
Adult: (IV infusion)4mg every 3 - 4 weeks
Schedule of Zoledronic acid
N/A
Storage Requirements for Zoledronic acid
Drug should be stored at room temperature 15-30 ?C. Keep out of the reach of children.
Effects of Missed Dosage of Zoledronic acid
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Zoledronic acid
Give symptomatic and supportive treatment.

Home Delivery for Zoledronic acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including zoledronic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for zoledronic acid and other medicines and health products. Home delivery services for zoledronic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take zoledronic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for zoledronic acid before they complete the sale. You can get this information while placing the order for zoledronic acid with the pharmacy.

Zoledronic acid is a generic medicine name and there are several brands available for it. Some of the brands for zoledronic acid might be better known than zoledronic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have zoledronic acid in stock, you can ask for one of the branded alternatives for zoledronic acid.