Loratadine Pharmacology

Loratadine

About Loratadine
Second Generation H1 Antagonist, Antihistamine.
Mechanism of Action of Loratadine
Loratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation (activation releasing other chemicals which produce the symptoms associated with allergy) of cells by histamine. Drug also has mast cell stabilizing property.
Pharmacokinets of Loratadine
Absorption- Rapidly absorbed after oral administration.
Distribution-Widely distributed in the body.97% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites, Descarboethoxyloratidine is its active metabolite.
Excretion- Excreted through both the urine and feces.
Onset of Action for Loratadine
1 - 3 hrs
Duration of Action for Loratadine
24 hrs
Half Life of Loratadine
N/A
Side Effects of Loratadine
1. Headache
2. Dry mouth, nose, and throat
3. Drowsiness
4. Rapid heartbeat
5. Difficulty urinating
6. Vision problems
7. Dizziness
8. Muscle weakness
9. Anxiety
10. Change in menstruation
11. Clumsiness
12. Depression
13. Feeling faint
14. Flushing of the face
15. Hallucinations
16. Migraines
17. Palpitations
18. Rash
19. Seizures
20. Shortness of breath
21. Sleeping disorders
22. Sore throat
23. Tightness in the chest or back
24. Yellowing of the eyes or skin
Contra-indications of Loratadine
1. Allergy to drug or any other antihistamines
2. Stenosing peptic ulcer
3. Symptomatic prostatic hypertrophy
4. Asthmatic attack
5. Bladder neck obstruction
6. Pyloroduodenal obstruction
7. Narrow-angle glaucoma
Special Precautions while taking Loratadine
Use with caution in patients with severe hepatic damage.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
NEONATES- Contraindicated
Indications for Loratadine
1. Allergic rhinitis (perennial and seasonal )
2. Vasomotor rhinitis
3. Allergic conjunctivitis
4. Urticaria( mild, uncomplicated )
5. Angioedema
6. Amelioration of allergic reactions to blood or plasma
7. Dermatographism
8. Adjunctive therapy in anaphylactic reactions
9. Decongestant

Interactions for Loratadine
Macrolide antibiotics, ketoconazole, cimetidine, ranitidine and theophylline: Caution should be exerted while co-administration of these drugs which are known to inhibit hepatic metabolism.
Typical Dosage for Loratadine
Oral-
General dose-
Adult-
10mg/day.
Children (>6) - Same as adult.

Schedule of Loratadine
N/A
Storage Requirements for Loratadine
Store it at room temperature and away from excess heat and moisture.
Effects of Missed Dosage of Loratadine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Loratadine
Give symptomatic and supportive treatment. Induce emesis except in patients with impaired consciousness. Then administer activated charcoal to adsorb any remaining drug. Provide gastric lavage if emesis is contraindicated.

Home Delivery for Loratadine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including loratadine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for loratadine and other medicines and health products. Home delivery services for loratadine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take loratadine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for loratadine before they complete the sale. You can get this information while placing the order for loratadine with the pharmacy.

Loratadine is a generic medicine name and there are several brands available for it. Some of the brands for loratadine might be better known than loratadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loratadine in stock, you can ask for one of the branded alternatives for loratadine.