Salmeterol Pharmacology

Salmeterol

About Salmeterol
A long-acting beta2-adrenergic agonist, Phenethylamine derivative, Bronchodilator(Antiasthma).
Mechanism of Action of Salmeterol
Salmeterol is a long acting ?2 receptor agonist. It directly relaxes the airway smooth muscles and produces bronchodilation. Stimulation of ?2 receptors activates Gs adenylyl-cyclase -cyclic AMP path way and produces reduction in smooth muscle tone. ?2 receptor agonists also increases the conductance of large Ca2+ sensitive K+ channels in airway smooth muscles and leads to membrane hyperpolarisation and relaxation of smooth muscles. Its ?2 receptor selectivity is about 50 times greater than Salbutamol.
?2 receptor agonists also suppress the release of Leukotrienes and histamine from the mast cells in the lung tissue and enhance mucociliary function and decrease micro vascular permeability and also inhibits Phospholipase A2 which produces inhibition of prostaglandins production. Thus Salmeterol can inhibit the broncho-constriction produced by inflammatory mediators.
Pharmacokinets of Salmeterol
Absorption: Systemic absorption is minimal.
Distribution: It is distributed in highly protein bound form (94 - 99%)
Metabolism: It is extensively metabolised by hydroxylation to alpha-hydroxy-Salmeterol
Excretion: It is excreted primarily in faeces.
Onset of Action for Salmeterol
10 - 20 minutes (inhalation)
Duration of Action for Salmeterol
12 hours
Half Life of Salmeterol
3 - 5 hours
Side Effects of Salmeterol
1. Cough
2. Diarrhoea
3. Nausea
4. Vomiting
5. Heart burn
6. Headache
7. Tremor
8. Muscle cramps
9. Nervousness
10. Palpitation
11. Sore throat
12. Nasopharyngitis
13. Tiredness
14. Skin rash
15. Muscle cramps
16. Tachycardia
Contra-indications of Salmeterol
1. Hypersensitivity to Salmeterol
Special Precautions while taking Salmeterol
1. Coronary insufficiency
2. Arrhythmia
3. Hypertension
4. Thyrotoxicosis
5. Epilepsy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Below 12 years: Contraindicated

Indications for Salmeterol
1. Reversible obstructive airway disease
2. Nocturnal asthma
3. Exercised induced Bronchospasm
Interactions for Salmeterol
N/A
Typical Dosage for Salmeterol
Adult: Long term maintenance treatment of asthma, Prevention of Bronchospasm, Reversible obstructive airway disease: 2Inhalations of 25mcg 2 times daily in the morning and in the evening. Dose can be increased to 100mcg if needed.
Prevention of exercised induced Bronchospasm:2 Inhalations of 25mcg 0.5 - 1 hour before exercise.
Chronic obstructive pulmonary disease or emphysema: single oral inhalation of 42 - 60 mcg.
Children above 12 years: same as adult dose.
Schedule of Salmeterol
H
Storage Requirements for Salmeterol
Store at 15 - 30 degree C.Protect from light. Do not freeze.
Effects of Missed Dosage of Salmeterol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Salmeterol
Give supportive measures and symptomatic treatment.

Home Delivery for Salmeterol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including salmeterol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for salmeterol and other medicines and health products. Home delivery services for salmeterol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take salmeterol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for salmeterol before they complete the sale. You can get this information while placing the order for salmeterol with the pharmacy.

Salmeterol is a generic medicine name and there are several brands available for it. Some of the brands for salmeterol might be better known than salmeterol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have salmeterol in stock, you can ask for one of the branded alternatives for salmeterol.