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- Pharmacology For Montelukast + Bambuterol
Montelukast + Bambuterol Pharmacology
Montelukast + Bambuterol
About Montelukast + BambuterolN/AMechanism of Action of Montelukast + BambuterolN/APharmacokinets of Montelukast + BambuterolN/AOnset of Action for Montelukast + BambuterolN/ADuration of Action for Montelukast + BambuterolN/AHalf Life of Montelukast + BambuterolN/ASide Effects of Montelukast + BambuterolN/AContra-indications of Montelukast + BambuterolN/ASpecial Precautions while taking Montelukast + BambuterolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Montelukast + BambuterolN/AInteractions for Montelukast + BambuterolN/ATypical Dosage for Montelukast + BambuterolN/ASchedule of Montelukast + BambuterolN/AStorage Requirements for Montelukast + BambuterolN/AEffects of Missed Dosage of Montelukast + BambuterolN/AEffects of Overdose of Montelukast + BambuterolN/AMontelukast
About MontelukastLeukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.Mechanism of Action of MontelukastMontelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.
Pharmacokinets of MontelukastAbsorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.
Onset of Action for MontelukastN/ADuration of Action for MontelukastN/AHalf Life of Montelukast2.75 - 5.5 hoursSide Effects of Montelukast1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia
Contra-indications of Montelukast1.Hypersensitivity to Montelukast
2.Acute asthmatic attacksSpecial Precautions while taking MontelukastN/APregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationMay be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated
Indications for MontelukastAsthma.Interactions for MontelukastBarbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
Typical Dosage for MontelukastAdult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time
Schedule of MontelukastN/AStorage Requirements for MontelukastStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of MontelukastTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MontelukastGive supportive measures and symptomatic treatmentBambuterol
About BambuterolLong acting beta 2-adrenoceptor agonist, anti asthmatic-bronchodilators.Mechanism of Action of BambuterolThis prodrug of the ?2-agonist terbutaline undergoes oxidation and hydrolysis in the body and converted into terbutaline. This terbutaline is a bronchodilator, a medication that dilates the air passages in the lungs by attachment to receptors on the muscle cells lining the air passages (beta adrenergic receptors) causing the muscles to relax, and in so doing it increases the diameter of the air passages so that more air can flow in and out of the lungs during breathing. It also relaxes some other types of smooth muscles, such as the muscles of the uterus.Pharmacokinets of BambuterolN/AOnset of Action for BambuterolN/ADuration of Action for BambuterolN/AHalf Life of BambuterolN/ASide Effects of Bambuterol1. Shakiness.
2. Nervous tension.
3. Headache.
4. Fast or fluttering heartbeat.
5. Disturbed sleep.
6. Behaviour changes in children.
7. Muscle cramps.Contra-indications of Bambuterol1. Hypersensitivity to the drug.
2. Acute asthma.
Special Precautions while taking Bambuterol1. Impaired renal function.
2. Impaired liver function.
3. Diabetes.
4. Severe thyrotoxicosis.
5. Severe cardiovascular disorders.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.Indications for Bambuterol1. Asthma.
2. Bronchitis.
3. EmphysemaInteractions for BambuterolSuccinylcholine (suxamethonium): Prolonged muscle relaxing effect.
b-blockers: May inhibit the effect of b-stimultants.
Xanthine derivatives, steroids & diuretic: Hypokalemia may be caused.
Typical Dosage for BambuterolAdult:
Initial recommended dose is 10 mg; which may be increased to 20 mg after 1-2 weeks depending on the clinical effect.
Children:
6 to 12 years: Initial dose 5 mg; which may be increased to 10 mg after 1-2 weeks depending on the effect.
2 to 5 years: Recommended normal dose is 5 mg. Dose above 10 mg are not recommended in children.
All doses are taken at once daily before bed time
Schedule of BambuterolN/AStorage Requirements for BambuterolStore in a cool dry place, away from direct heat and light. Keep out of reach of children.Effects of Missed Dosage of BambuterolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BambuterolGive symptomatic and supportive (cardiac and respiratory) treatment. Induce emesis and gastric lavage if necessary. Monitor vital signs closely. Home Delivery for Montelukast + Bambuterol in Your City
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Montelukast + Bambuterol is a generic medicine name and there are several brands available for it. Some of the brands for montelukast + bambuterol might be better known than montelukast + bambuterol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have montelukast + bambuterol in stock, you can ask for one of the branded alternatives for montelukast + bambuterol.