Sodium Cromoglycate Pharmacology

Sodium Cromoglycate

About Sodium Cromoglycate
Synthetic chromone derivative, Mast Cell Stabilizer, Antiallergic, asthma prophylactic.
Mechanism of Action of Sodium Cromoglycate
This synthetic chromone derivative has several mechanism of action 1. It is a mast cell stabilizer 2. It inhibit chloride channels and inhibit the exaggerated neuronal reflexes triggered by stimulation of irritant receptors on sensory nerve endings (e.g. exercise-induced asthma) and release of preformed cytokines from several type of inflammatory cells (T-cell, Eosinophil) in allergen-induced asthma.3. It inhibit calcium influx of the cell 4.It inhibit the enzyme phosphodiesterase 5. It reduce alpha-adrenoreceptor density 6. It inhibit Ig-E dependant secretion of cells other than mast cells.
Pharmacokinets of Sodium Cromoglycate
Absorption- Poorly after intranasal administration. The drug is deposited (8-10%) to the lungs. From the lungs the drug is rapidly absorbed.
Excretion- Excreted unchanged via urine and bile

Onset of Action for Sodium Cromoglycate
NULL.
Duration of Action for Sodium Cromoglycate
NULL.
Half Life of Sodium Cromoglycate
N/A
Side Effects of Sodium Cromoglycate
1. Throat irritation or dryness
2. Bad taste
3. Cough
4. Wheeze
5. Nausea
6. Bronchospasm
7. Laryngeal edema
8. Nasal congestion
9. Pharyngeal irritation
10. Anaphylaxis
11. Angioedema
12. Dizziness
13. Dysuria
14. Urinary frequency
15. Joint swelling and pain
16. Lacrimation
17. Headache
18. Rash
19. Swollen parotid gland
20. Urticaria

Contra-indications of Sodium Cromoglycate
1.Hypersensitivity to drug or any of its components
Special Precautions while taking Sodium Cromoglycate
Sudden withdrawal may cause allergic symptoms.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Sodium Cromoglycate
1. Adjunct in the management of intrinsic and extrinsic asthma
2. Prevention of bronchospasm induced by known precipitating factors such as exercise, cold air, allergens and environmental pollutants
3. Allergic rhinitis
4. Hay fever


Interactions for Sodium Cromoglycate
NULL.
Typical Dosage for Sodium Cromoglycate
Adult-
Intranasal-
2-3 drops in each nostril 2-3 times daily.
Intraoccular-
1-2 drops into each eye 4 times daily.

Schedule of Sodium Cromoglycate
H
Storage Requirements for Sodium Cromoglycate
Stored at room temperature. Keep out of reach of children.
Effects of Missed Dosage of Sodium Cromoglycate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sodium Cromoglycate
Give symptomatic and supportive treatment

Home Delivery for Sodium Cromoglycate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sodium cromoglycate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sodium cromoglycate and other medicines and health products. Home delivery services for sodium cromoglycate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sodium cromoglycate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sodium cromoglycate before they complete the sale. You can get this information while placing the order for sodium cromoglycate with the pharmacy.

Sodium Cromoglycate is a generic medicine name and there are several brands available for it. Some of the brands for sodium cromoglycate might be better known than sodium cromoglycate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sodium cromoglycate in stock, you can ask for one of the branded alternatives for sodium cromoglycate.