Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid Pharmacology

Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid

About Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Mechanism of Action of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
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Pharmacokinets of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
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Onset of Action for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Duration of Action for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Half Life of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Side Effects of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Contra-indications of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Special Precautions while taking Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Pregnancy Related Information
Contraindicated; since Codeine and Chlorpheniramine Maleate are contraindicated in pregnancy, the combination generic cannot be used in pregnancy
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Chlorpheniramine Maleate and Guaiphensin are contraindicated in breast feeding; the combination generic cannot be used in breast feeding mother
Children Related Information
N/A
Indications for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
Cough
Interactions for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Typical Dosage for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
5 ml to be taken 3 times daily.
Schedule of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Storage Requirements for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Effects of Missed Dosage of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A
Effects of Overdose of Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid
N/A

Codeine

About Codeine
An opiate, methylmorphine , Narcotic analgesic, antitussive, and antidiarrheal.
Mechanism of Action of Codeine
Codeine exerts it`s action through opioid receptors and posses antitussive properties. It selectively and directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptors.
Pharmacokinets of Codeine
Absorption: Well absorbed after oral and parenteral administration. Distribution: Widely distributed in the body; it crosses placenta and also enters in to the breast milk. Metabolism: Metabolized in the liver by demethylation and glucuronide conjugation, Excretion: Excreted mainly in the urine as nor codeine and free and conjugated morphine.
Onset of Action for Codeine
Oral: 30 to 45 minutes
I.V.: Rapid
I.M.: 10 to 30 minutes
S.C.: 10 to 30 minutes
Duration of Action for Codeine
Oral: 4 to 6 hours
I.V.: 4 to 6 hours
I.M.: 4 to 6 hours
S.C.: 4 to 6 hours
Half Life of Codeine
N/A
Side Effects of Codeine
1. Constipation
2. Nausea
3. Vomiting
4. Drymouth
5. Respiratory depression
6. Hypotension
7. Bradycardia
8. Dizziness
9. Sedation
10. Euphoria
11. Urine retention
12. Flushing
13. Pruritus
14. Diaphoresis
15. Physical dependence.
Contra-indications of Codeine
1. Hypersensitivity to the drug
2. Bronchial asthma
3. Increased intracranial pressure
4. Respiratory depression
5. Paralytic ileus
6. Head injury
7. Alcoholism
8. Diverticulitis
9. Following bowel surgery.
Special Precautions while taking Codeine
1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
4. Hypothyroidism
5. Addison`s disease
6. COPD
7. In deliberate individuals
8. Prostatic hypertrophy
9. Epilepsy
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Codeine
1. Nonproductive cough
2. Mild to moderate pain.
Interactions for Codeine
N/A
Typical Dosage for Codeine
Adults:
Oral:
Nonproductive cough:10 to 20mg 4 times daily;Maximum dose: 120mg/day
Oral, S.C., I.M.:
Mild to moderate pain:15 to 60mg Orally, S.C., or I.M.;4 to 6 times daily as required by the patient.

Children:
Oral:
Nonproductive cough:
Over 12 years: 10 to 20mg 4 times daily
Age 6 to 12: 5 to 10mg 4 times daily;Maximum dose: 60mg/day
Age 2 to 6: 1mg/kg/day as four equally divided doses and do not exceed 30mg in 24 hours.
Oral, S.C., I.M.:
Mild to moderate pain:0.5mg/kg orally every 4 to 6 hours or 0.5mg/kg S.C. or I.M.
Schedule of Codeine
H
Storage Requirements for Codeine
Store at controlled room temperature at a range of 15 to 30 degree C and protects from light.
Effects of Missed Dosage of Codeine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Codeine
Establish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.

Guaiphenesin

About Guaiphenesin
Propanediol derivative, Expectorant.
Mechanism of Action of Guaiphenesin
Guaiphenesin is an expectorant which after absorption from the gastrointestinal tract secreted by tracheobronchial glands and directly increase bronchial secretion and mucosal ciliary action. It increases respiratory tract fluid by reducing adhesiveness and surface tension, reducing viscosity of the secretions and there by facilitating their removal and clears chest congestion.
Action in local vaginal preparations: Guaiphenesin helps to thin the thick or sticky cervical mucus.

Pharmacokinets of Guaiphenesin
Absorption: Well absorbed orally.Distribution: It is secreted by the tracheobronchial glands.
Metabolism: It is metabolized primarily to Beta-2-methoxyphenoxy-lactic acid. Excretion: It is excreted in the urine.
Onset of Action for Guaiphenesin
N/A
Duration of Action for Guaiphenesin
N/A
Half Life of Guaiphenesin
60 minutes
Side Effects of Guaiphenesin
1. Headache
2. Dizziness
3. Nausea
4. Vomiting
5. Rash
6. Diarrhoea
7. Drowsiness
8. Stomach pain
Contra-indications of Guaiphenesin
1. Hypersensitivity to the drug
2. Chronic or persistent cough associated with chronic lower respiratory tract diseases
3. Asthma
4. Bronchitis
5. Chronic obstructive pulmonary disease (COPD)
6. Emphysema
Special Precautions while taking Guaiphenesin
1. Porphyria
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Guaiphenesin
1. Expectorant
2. Thick or sticky cervical mucus
Interactions for Guaiphenesin
N/A
Typical Dosage for Guaiphenesin
Oral :
Adults and children over 12 years: 100 to 400mg up to 6 times daily as required.Maximum dose: 2.4g/day
Children (age 6 to 11): 100 to 200mg up to 6 times daily as required.Maximum dose: 1.2g/day
Children (age 2 to 5): 50 to 100mg up to 6 times daily as required.Maximum dose: 600mg/day
Extended release:
Adults and children over 12 years: 600 to 1200mg twice daily. Not to exceed 2.4g in 24 hours
Children (age 6 to 12): 600mg twice daily. Not to exceed 1.2g in 24 hours
Children (age 2 to 6): 300mg twice daily. Not to exceed 600mg in 24 hours
Thick or sticky cervical mucus: 200mg 2 to 3 times daily from 4 days prior to ovulation and continue through ovulation day.
Schedule of Guaiphenesin
N/A
Storage Requirements for Guaiphenesin
Store at a temperature below 30 degree C. Keep out of reach of children.
Effects of Missed Dosage of Guaiphenesin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Guaiphenesin
Provide symptomatic treatment and supportive measures.

Sodium citrate

About Sodium citrate
Sodium compound,citrates, Urinary alkalinizing agent, a directly acing expectorant.
Mechanism of Action of Sodium citrate
Sodium citrate is an alkalinizing agent which is used to make the urine more alkaline (less acidic).It prevents certain kinds of kidney stones and also relieve discomfort in mild urinary tract infections such as cystitis. Sodium citrate also makes the blood more alkaline in certain conditions. Sodium citrate is a directly acing expectorant which increases bronchial secretion by salt action.
Pharmacokinets of Sodium citrate
Absorption: Administered orally, Metabolism: Metabolized in to sodium bicarbonate, Excretion: Excreted through urine.
Onset of Action for Sodium citrate
N/A
Duration of Action for Sodium citrate
N/A
Half Life of Sodium citrate
N/A
Side Effects of Sodium citrate
1. Polyuria
2. Hypernatremia
3. Metabolic alkalosis
4. Diarrhea
5. Loose bowel movements
6. Allergic reactions (rare)
7. Chest pain (rare)
8. Shortness of breath (rare)
Contra-indications of Sodium citrate
Hypersensitivity to the drug
Special Precautions while taking Sodium citrate
1. Renal impairment
2. Edema
3. Hypertension
4. Patients on a sodium restricted diet
5. Along with other medication
6. Addison`s disease
7. Type 2 diabetes mellitus
8. Chronic Diarrhea
9. Cardiac diseases
10. Toxemia of pregnancy
11. Urinary tract infections
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Sodium citrate
1. Expectorant
2. Kidney stones
3. Cystitis
4. Gout
5. Urine and blood alkaliniser
6. Symptomatic treatment of nausea and vomiting
Interactions for Sodium citrate
N/A
Typical Dosage for Sodium citrate
Oral:
Expectorant: 0.3 to 1g
As alkaliniser: Dosage individualized and varies in different combinations Symptomatic treatment of nausea and vomiting: Use 5%Sodium citrate in the following doses:
Adults: 2 to3 g; 3 to 4 times daily.
Children (up to 3 months): 0.05 g;
Children (3 to 6 months): 0.1 g;
Children (6 to 12 months): 0.25 g;
Children (2 to 3 years): 0.30 g;
Children (4 to 7 years): 0.50 g;
Children (8 to 14 years): 1 to 2 g; 3 to 4 times daily
Schedule of Sodium citrate
N/A
Storage Requirements for Sodium citrate
Store in a cool dry area in a tightly closed container. Protect from direct light, heat, and moisture
Effects of Missed Dosage of Sodium citrate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Sodium citrate
Provide symptomatic treatment and supportive measures.

Phenylephrine

About Phenylephrine
An a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.
Mechanism of Action of Phenylephrine
The drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.
Pharmacokinets of Phenylephrine
Absorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.
Onset of Action for Phenylephrine
Nasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes
Duration of Action for Phenylephrine
Nasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.


Half Life of Phenylephrine
N/A
Side Effects of Phenylephrine
1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis


Contra-indications of Phenylephrine
1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)
Special Precautions while taking Phenylephrine
1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below age 6:contraindicated
Indications for Phenylephrine
1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract

Interactions for Phenylephrine
May interact with systemically administered MAOIs.
Typical Dosage for Phenylephrine
I.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.
Schedule of Phenylephrine
N/A
Storage Requirements for Phenylephrine
Store at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.
Effects of Missed Dosage of Phenylephrine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phenylephrine
Discontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.

Chlorpheniramine Maleate

About Chlorpheniramine Maleate
N/A
Mechanism of Action of Chlorpheniramine Maleate
N/A
Pharmacokinets of Chlorpheniramine Maleate
N/A
Onset of Action for Chlorpheniramine Maleate
N/A
Duration of Action for Chlorpheniramine Maleate
N/A
Half Life of Chlorpheniramine Maleate
N/A
Side Effects of Chlorpheniramine Maleate
N/A
Contra-indications of Chlorpheniramine Maleate
First Generation alkylamine H1 Antagonist, Antihistamine.
Special Precautions while taking Chlorpheniramine Maleate
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Chlorpheniramine Maleate
N/A
Interactions for Chlorpheniramine Maleate
N/A
Typical Dosage for Chlorpheniramine Maleate
N/A
Schedule of Chlorpheniramine Maleate
N/A
Storage Requirements for Chlorpheniramine Maleate
N/A
Effects of Missed Dosage of Chlorpheniramine Maleate
N/A
Effects of Overdose of Chlorpheniramine Maleate
N/A

Chloroform

About Chloroform
Trihalomethanes, Anesthetic, Antispasmodic, And Sedative.
Mechanism of Action of Chloroform
N/A
Pharmacokinets of Chloroform
N/A
Onset of Action for Chloroform
N/A
Duration of Action for Chloroform
N/A
Half Life of Chloroform
N/A
Side Effects of Chloroform
N/A
Contra-indications of Chloroform
N/A
Special Precautions while taking Chloroform
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Chloroform
N/A
Interactions for Chloroform
N/A
Typical Dosage for Chloroform
N/A
Schedule of Chloroform
N/A
Storage Requirements for Chloroform
N/A
Effects of Missed Dosage of Chloroform
N/A
Effects of Overdose of Chloroform
N/A

Citric acid

About Citric acid
Weak organic carboxylic acid, an alkalinizing agent, expectorant, antioxidant, flavouring agent.
Mechanism of Action of Citric acid
Citric acid is an organic acid which is used widely in medicine and also as flavouring agent. Citric acid is an alkalinizing agent which is used to make the urine more alkaline (less acidic).It prevents certain kinds of kidney stones. It is used in expectorant preparations to increase bronchial secretion. It also posses antioxidant properties.
Pharmacokinets of Citric acid
Absorption: Administered orally, Excretion: Excreted through urine.
Onset of Action for Citric acid
N/A
Duration of Action for Citric acid
N/A
Half Life of Citric acid
N/A
Side Effects of Citric acid
1 Polyuria
2.Hypernatremia
3.Metabolic alkalosis
4.Diarrhea
5.Loose bowel movements
6.Allergic reactions (rare)
7.Chest pain (rare)
8.Shortness of breath(rare)
Contra-indications of Citric acid
1.Hypersensitivity to the drug
2.Patients on sodium-restricted diets
3.Renal impairment with oliguria, azotemia, or anuria
4.Acute dehydration
5.Heat cramps
6.Severe myocardial damage
7.Hyperkalemia.
Special Precautions while taking Citric acid
1.Renal impairment
2.Edema
3.Hypertension
4.Along with other medication
5.Addison`s disease
6.Type 2 diabetes mellitus
7.Urolithiasis
8.Cardiac diseases
9.Toxemia of pregnancy
10.Urinary tract infections
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Citric acid
1.Expectorant
2.Kidney stones
3.Gout
4.Urine and blood alkaliniser
5.Symptomatic treatment of nausea and vomiting
Interactions for Citric acid
N/A
Typical Dosage for Citric acid
Oral:
As alkaliniser: Dosage are individualized and varies in different combinations
Schedule of Citric acid
N/A
Storage Requirements for Citric acid
Store in a cool dry area in a tightly closed container. Protect from direct light, heat, and moisture.
Effects of Missed Dosage of Citric acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Citric acid
Provide symptomatic treatment and supportive measures.

Home Delivery for Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid in Your City

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Codeine + Guaiphenesin + Sodium citrate + Phenylephrine + Chlorpheniramine Maleate + Chloroform +Citric acid is a generic medicine name and there are several brands available for it. Some of the brands for codeine + guaiphenesin + sodium citrate + phenylephrine + chlorpheniramine maleate + chloroform +citric acid might be better known than codeine + guaiphenesin + sodium citrate + phenylephrine + chlorpheniramine maleate + chloroform +citric acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have codeine + guaiphenesin + sodium citrate + phenylephrine + chlorpheniramine maleate + chloroform +citric acid in stock, you can ask for one of the branded alternatives for codeine + guaiphenesin + sodium citrate + phenylephrine + chlorpheniramine maleate + chloroform +citric acid.