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- Pharmacology For Ammonium chloride + Sodium citrate + Methdilazine
Ammonium chloride + Sodium citrate + Methdilazine Pharmacology
Ammonium chloride + Sodium citrate + Methdilazine
About Ammonium chloride + Sodium citrate + MethdilazineN/AMechanism of Action of Ammonium chloride + Sodium citrate + MethdilazineN/APharmacokinets of Ammonium chloride + Sodium citrate + MethdilazineN/AOnset of Action for Ammonium chloride + Sodium citrate + MethdilazineN/ADuration of Action for Ammonium chloride + Sodium citrate + MethdilazineN/AHalf Life of Ammonium chloride + Sodium citrate + MethdilazineN/ASide Effects of Ammonium chloride + Sodium citrate + MethdilazineN/AContra-indications of Ammonium chloride + Sodium citrate + MethdilazineN/ASpecial Precautions while taking Ammonium chloride + Sodium citrate + MethdilazineN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Methdilazine is contraindicated in breast feeding mother, the combination generic cannot be used in lactation.Children Related InformationN/AIndications for Ammonium chloride + Sodium citrate + Methdilazine1.Productive cough
Interactions for Ammonium chloride + Sodium citrate + MethdilazineN/ATypical Dosage for Ammonium chloride + Sodium citrate + MethdilazineAdult: 1 - 2 teaspoonful to be taken 3 - 4imes daily.Schedule of Ammonium chloride + Sodium citrate + MethdilazineN/AStorage Requirements for Ammonium chloride + Sodium citrate + MethdilazineN/AEffects of Missed Dosage of Ammonium chloride + Sodium citrate + MethdilazineN/AEffects of Overdose of Ammonium chloride + Sodium citrate + MethdilazineN/AAmmonium chloride
About Ammonium chlorideAmmonium compound, Acidifier,Expectorant.Mechanism of Action of Ammonium chlorideN/APharmacokinets of Ammonium chlorideN/AOnset of Action for Ammonium chlorideN/ADuration of Action for Ammonium chlorideN/AHalf Life of Ammonium chlorideN/ASide Effects of Ammonium chlorideN/AContra-indications of Ammonium chlorideN/ASpecial Precautions while taking Ammonium chlorideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ammonium chlorideN/AInteractions for Ammonium chlorideN/ATypical Dosage for Ammonium chlorideN/ASchedule of Ammonium chlorideN/AStorage Requirements for Ammonium chlorideN/AEffects of Missed Dosage of Ammonium chlorideN/AEffects of Overdose of Ammonium chlorideN/ASodium citrate
About Sodium citrateSodium compound,citrates, Urinary alkalinizing agent, a directly acing expectorant.Mechanism of Action of Sodium citrateSodium citrate is an alkalinizing agent which is used to make the urine more alkaline (less acidic).It prevents certain kinds of kidney stones and also relieve discomfort in mild urinary tract infections such as cystitis. Sodium citrate also makes the blood more alkaline in certain conditions. Sodium citrate is a directly acing expectorant which increases bronchial secretion by salt action.Pharmacokinets of Sodium citrateAbsorption: Administered orally, Metabolism: Metabolized in to sodium bicarbonate, Excretion: Excreted through urine.Onset of Action for Sodium citrateN/ADuration of Action for Sodium citrateN/AHalf Life of Sodium citrateN/ASide Effects of Sodium citrate1. Polyuria
2. Hypernatremia
3. Metabolic alkalosis
4. Diarrhea
5. Loose bowel movements
6. Allergic reactions (rare)
7. Chest pain (rare)
8. Shortness of breath (rare)
Contra-indications of Sodium citrateHypersensitivity to the drugSpecial Precautions while taking Sodium citrate1. Renal impairment
2. Edema
3. Hypertension
4. Patients on a sodium restricted diet
5. Along with other medication
6. Addison`s disease
7. Type 2 diabetes mellitus
8. Chronic Diarrhea
9. Cardiac diseases
10. Toxemia of pregnancy
11. Urinary tract infections
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Sodium citrate1. Expectorant
2. Kidney stones
3. Cystitis
4. Gout
5. Urine and blood alkaliniser
6. Symptomatic treatment of nausea and vomiting
Interactions for Sodium citrateN/ATypical Dosage for Sodium citrateOral:
Expectorant: 0.3 to 1g
As alkaliniser: Dosage individualized and varies in different combinations Symptomatic treatment of nausea and vomiting: Use 5%Sodium citrate in the following doses:
Adults: 2 to3 g; 3 to 4 times daily.
Children (up to 3 months): 0.05 g;
Children (3 to 6 months): 0.1 g;
Children (6 to 12 months): 0.25 g;
Children (2 to 3 years): 0.30 g;
Children (4 to 7 years): 0.50 g;
Children (8 to 14 years): 1 to 2 g; 3 to 4 times daily
Schedule of Sodium citrateN/AStorage Requirements for Sodium citrateStore in a cool dry area in a tightly closed container. Protect from direct light, heat, and moistureEffects of Missed Dosage of Sodium citrateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sodium citrateProvide symptomatic treatment and supportive measures.Methdilazine
About MethdilazineFirst generation H1 antagonist, Phenothiazine Tricyclic derivative, Antihistamine.Mechanism of Action of MethdilazineMethdilazine is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract and bind to it. This results the prevention of activation of histamines (which are responsible for allergic symptoms). It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergiesPharmacokinets of MethdilazineAbsorption- Well absorbed after oral administration
Distribution- Widely distributed in the body. 65-90% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted via urine
Onset of Action for Methdilazine15-60 minDuration of Action for Methdilazine6-12 hrsHalf Life of MethdilazineIts plasma half life is 7-14 hrsSide Effects of Methdilazine1. Stomach pain
2. Rash
3. Black, tarry stools
4. Bleeding gums
5. Blood in urine or stools
6. Bloody nose
7. Bluish skin or lips chest pain chills
8. Confusion
9. Tinnitus
10. Convulsions
11. Cough or hoarseness
12. Difficult or troubled breathing
13. Difficulty in speaking
14. Drooling
15. Fainting
16. Fever with or without chills
17. Fixed position of eye
18. Weakness
19. Headache
20. Hearing loss
21. Heavier menstrual periods
22. High or low blood pressure
23. Hives
24. Hysteria
25. Itching
26. Lightheadedness
27. Loss of balance control
28. Loss of bladder control
29. Lower back or side pain
30. Muscle pain or weakness
31. Muscle spasm or jerking of all extremities
32. Nausea
33. Sore throat
34. Sores, ulcers, or white spots on lips or in mouth
35. Unpleasant breath odorContra-indications of Methdilazine1. Hypersensitivity to the drug or other ingredients
2. Narrow angle glaucoma
3. Paralytic ileus
4. Urinary tract obstruction
Special Precautions while taking Methdilazine1. Blood disease
2. Enlarged prostate gland
3. Urinary tract blockage or difficult urination
4. Epilepsy
5. Glaucoma
6. Jaundice
7. Liver disease
8. Reye`s syndrome
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES- ContraindicatedIndications for Methdilazine1. Allergy
2. Pruritis
3. Urticaria
4. Motion sickness
5. Vertigo
6. Angioedema
7. Dermatographism
8. Sneezing
9. Rhinorrhea
Interactions for MethdilazineAlcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, narcotic analgesics): Leads to potentiation of CNS depression.
MAOIs: Prolong and intensify anticholinergic effects.
Atropine and tricyclic antidepressants: Potentiate antimuscarinic effects.
Aminoglycosides: Ototoxicity of aminoglycosides masked.Typical Dosage for MethdilazineOral-
General dose-
Adult-8mg or 10ml syrup twice daily
Children-5ml syrup twice daily
Schedule of MethdilazineN/AStorage Requirements for MethdilazineStored at room temperature. Protect from light and excessive heat. Keep out of reach of childrenEffects of Missed Dosage of MethdilazineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MethdilazineGive symptomatic and supportive treatment. Induce emesis or gastric lavage. Treat with vasopressors for hypotension and antiepileptic for convulsionsHome Delivery for Ammonium chloride + Sodium citrate + Methdilazine in Your City
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