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- Pharmacology For Dextromethorphan + Pseudoephedrine + Levocetirizine
Dextromethorphan + Pseudoephedrine + Levocetirizine Pharmacology
Dextromethorphan + Pseudoephedrine + Levocetirizine
About Dextromethorphan + Pseudoephedrine + LevocetirizineN/AMechanism of Action of Dextromethorphan + Pseudoephedrine + LevocetirizineN/APharmacokinets of Dextromethorphan + Pseudoephedrine + LevocetirizineN/AOnset of Action for Dextromethorphan + Pseudoephedrine + LevocetirizineN/ADuration of Action for Dextromethorphan + Pseudoephedrine + LevocetirizineN/AHalf Life of Dextromethorphan + Pseudoephedrine + LevocetirizineN/ASide Effects of Dextromethorphan + Pseudoephedrine + LevocetirizineN/AContra-indications of Dextromethorphan + Pseudoephedrine + LevocetirizineN/ASpecial Precautions while taking Dextromethorphan + Pseudoephedrine + LevocetirizineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dextromethorphan + Pseudoephedrine + LevocetirizineN/AInteractions for Dextromethorphan + Pseudoephedrine + LevocetirizineN/ATypical Dosage for Dextromethorphan + Pseudoephedrine + LevocetirizineN/ASchedule of Dextromethorphan + Pseudoephedrine + LevocetirizineN/AStorage Requirements for Dextromethorphan + Pseudoephedrine + LevocetirizineN/AEffects of Missed Dosage of Dextromethorphan + Pseudoephedrine + LevocetirizineN/AEffects of Overdose of Dextromethorphan + Pseudoephedrine + LevocetirizineN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Levocetirizine
About LevocetirizineA third-generation non-sedative H1 antagonist, Antihistamine.Mechanism of Action of LevocetirizineThis active enantiomer of cetrizine is a potent, nonsedative and selective H1 receptor antagonist. It antagonizes the allergic symptoms produced by histamines like runny nose, cold, cough etc. It also inhibit eotaxin-induced eosinophil TEM through both dermal and lung micro vascular endothelial cells. So inhibit eosinophil chemotaxis and also inflammation caused by it.Pharmacokinets of LevocetirizineAbsorption- Well absorbed after oral administration.
Distribution-Widely distributed in the body.90% bound to the plasma proteins.
Metabolism- Metabolized in the liver to its metabolites.
Excretion- Excreted via urine and feces.
Onset of Action for LevocetirizineN/ADuration of Action for LevocetirizineN/AHalf Life of LevocetirizineIts plasma half life is 6-10hrsSide Effects of Levocetirizine1. Headache
2. Abdominal pain
3. Dry mouth
4. Fatigue
5. Pharyngitis
6. Sleepiness
7. Asthenia
8. Rhinitis causing a blocked or runny nose
9. Migraine
Contra-indications of Levocetirizine1. Allergy to drug or other medicines that contain piperazine derivatives
2. Hereditary galactose intolerance
3. Hereditary Lapp lactase deficiency
4. Inherited glucose-galactose malabsorption
5. Severely decreased kidney function
Special Precautions while taking Levocetirizine1. Decreased kidney function
2. Avoid alcohol or any work which require mental alertness like driving and machine operation during treatment.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Levocetirizine1. Rhinitis (seasonal and perennial)
2. Idiopathic urticaria
Interactions for LevocetirizineCoadministration with alcohol or other CNS depressants may have additional CNS depressant effect. Typical Dosage for LevocetirizineOral-
Adult-5mg/day.
Children (>6yrs) - 5mg/day. Schedule of LevocetirizineN/AStorage Requirements for LevocetirizineStore in a cool, dry place, away from direct light and heat.
Keep out of reach of children.
Effects of Missed Dosage of LevocetirizineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of LevocetirizineGive symptomatic and supportive treatment.Home Delivery for Dextromethorphan + Pseudoephedrine + Levocetirizine in Your City
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Please be aware that you should take dextromethorphan + pseudoephedrine + levocetirizine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dextromethorphan + pseudoephedrine + levocetirizine before they complete the sale. You can get this information while placing the order for dextromethorphan + pseudoephedrine + levocetirizine with the pharmacy.
Dextromethorphan + Pseudoephedrine + Levocetirizine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + pseudoephedrine + levocetirizine might be better known than dextromethorphan + pseudoephedrine + levocetirizine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + pseudoephedrine + levocetirizine in stock, you can ask for one of the branded alternatives for dextromethorphan + pseudoephedrine + levocetirizine.